Date: Monday, June 5, 2017
Session Title: Parkinsonism, MSA, PSP (Secondary and Parkinsonism-Plus)
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: To investigate the association between findings of night video-polysomnography and clinical feature of patients with multiple system atrophy (MSA).
Background: Nocturnal sleep-related clinical sympotoms are prevalent in MSA patients and critical in some patients. However, little has been known about the objective polysomnographic findings in MSA patients and their clinical implications.
Methods: We retrospectively analyzed clinical data of MSA patients (N = 49) who underwent an overnight vido-polysomnography. Stridor was defined as present when confirmed by an overnight video-polysomnography. The video-polysomnographic findings and clinical features of MSA patients were compared between MSA patients with stridor and those without.
Results: The mean age at onset was 55.7 ± 8.9 years and mean disease duration of MSA was 43.5 ± 24.0 months. Thirty–one (63.3%) of the 49 MSA patients were assessed as having the stridor. MSA patients with stridor showed significantly higher apnea-hypopnea index (31.3 ± 21.8/hr versus 18.7 ± 18.2/hr, p = 0.024), respiratory disturbance index (35.6 ± 22.4/hr versus 23.3 ± 21.1/hr, p = 0.049), and oxygen desaturation index (31.6 ± 21.3/hr versus 16.3 ± 18.6/hr, p = 0.006), compared with those without stridor. The axial motor features of MSA were more severe in MSA patients with stridor than those without (p = 0.017). However, there was no significant difference of sex, age at onset, subtypes of MSA, parkinsonian features, cerebellar ataxia, and autonomic dysfunction between MSA patients with stridor and those without. In logistic regression analysis, longer disease duration (p = 0.04) and more severe axial motor features (P = 0.036) were associated with the presence of nocturnal stridor in MSA patients.
Conclusions: Our results suggest that MSA patients with nocturnal stridor had more severe sleep disordered breathing and nocturnal hypoxemia during sleep. Stridor in MSA was associated with severe axial motor features of MSA.
To cite this abstract in AMA style:H.-S. Ryu, J.-H. Paek, S. You, M.-J. Kim, Y.J. Kim, J. Kim, K. Kim, S.-A. Lee, S.J. Chung. Association of nocturnal stridor with clinical features of patients with multiple system atrophy [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/association-of-nocturnal-stridor-with-clinical-features-of-patients-with-multiple-system-atrophy/. Accessed December 9, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/association-of-nocturnal-stridor-with-clinical-features-of-patients-with-multiple-system-atrophy/