Session Information
Date: Tuesday, September 24, 2019
Session Title: Parkinsonisms and Parkinson-Plus
Session Time: 1:45pm-3:15pm
Location: Agora 3 West, Level 3
Objective: Our hypothesis is BBB disruption causes idiopathic adult onset ventriculomegaly (IAOV) also, astrocyte specific mitochondrial dysfunction is associated with BBB damage.
Background: The cause of IAOV which mentioned generally normal pressure hydrocephalus did not known yet. However, dysfunction of blood brain barrier (BBB) affects reabsorption of cerebrospinal fluid (CSF) and patients with IAOV observed high resistance for absorption of CSF, in many studies. BBB consisted of astrocyte and endothelial cells, also the tight junctions which regulate paracellular transport need high energy such as ATP.
Method: A total of 20 patients and 20 age-matched controls were included. The patients with IAOV who showed triad such as gait disturbance, urinary urgency and cognitive impairment, besides, Evan’s ratio > 0.3 in brain MRI were enrolled. Age-matched controls were selected who did not have neurological symptoms. The CSF markers stand for the BBB disruption therefore astrocyte specific markers which associate with mitochondria dysfunctions were selected. LCN2, HMGb1, FGF21, GDF15 levels (pg~ng/ml) of CSF were analyzed using ELISA kit, and these levels were compared between patients and age-matched controls.
Results: The FGF21 levels in CSF between two groups did not showed statistical significance (p = 0.157). And GDF15 levels in CSF also showed any difference (p = 0.174). However, LCN2 (astrocyte specific markers) levels in CSF were detected significantly higher in IAOV patients group than controls (p < 0.023). Furthermore, HMGb1 levels which stand for mitochondrial damage showed definite higher in patients’ CSF than controls (p < 0.044).
Conclusion: In this study, LCN2 and HMGb1 levels in CSF which associated with astrocyte specific mitochondrial dysfunction were increased in IAOV patients. Therefore, the BBB damage caused by age related mitochondrial dysfunction is a kind of pathomechanism in IAOV.
To cite this abstract in AMA style:
E. Oh, H. Chang, S. Kim, S. Kim, J. Heo. Blood brain barrier dysfunction cause idiopathic adult onset ventriculomegaly? [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/blood-brain-barrier-dysfunction-cause-idiopathic-adult-onset-ventriculomegaly/. Accessed June 14, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/blood-brain-barrier-dysfunction-cause-idiopathic-adult-onset-ventriculomegaly/