Session Information
Date: Tuesday, September 24, 2019
Session Title: Parkinsonisms and Parkinson-Plus
Session Time: 1:45pm-3:15pm
Location: Agora 3 West, Level 3
Objective: To investigate cerebellar involvement in vivo in patients with corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) using [18F]FDG PET.
Background: Cerebellar ataxia is an exclusion criterion for CBD or PSP. However, cerebellar involvement in pathologically proven PSP cases has been reported. We investigated the frequency, clinical manifestations and diagnostic imaging of CBD or PSP with prominent cerebellar ataxia.
Method: Consecutive patients diagnosed with CBD or PSP between January 2009 and January 2019 were reviewed from atypical parkinsonism database. Clinical data were abstracted from medical records, mainly at the time of the diagnosis with neuroimaging. Patients who had cerebellar ataxia (either limb ataxia or gait ataxia) on the neurological examination, and who also had cerebellar hypometabolism in [18F]FDG-PET were evaluated. [18F]FDG-PET was analyzed by single-subject SPM analysis, followed by region-of-interest (ROI) based analysis. The regional glucose uptake in the cerebellum, which was expressed as z scores, was compared between PSP and CBD patients.
Results: Among 41 patients with clinically diagnosed PSP, 21 patients had cerebellar ataxia (PSP-C) on neurological examination. Among 27 patients with clinically diagnosed CBD, 10 patients showed cerebellar ataxia or were in bed-ridden state(CBD-C). Gait ataxia was more prominent than limb ataxia in patients with PSP-C and CBD-C. Ocular cerebellar signs, such as hypermetria or nystagmus, were not present in patients with PSP-C and CBD-C. Patients with PSP showed significant hypometabolism in the superior and anterior vermis, and anterior lobe of cerebellum when compared with patients with CBD(Figure1, error bar = 1 SEM).
Conclusion: Cerebellar involvement is present in some patients with PSP or CBD. In particular, patients with PSP-C exhibited hypometabolism of superior, anterior part of vermis, and anterior lobe of cerebellum in [18F]FDG-PET, which accounts for prominent gait ataxia in these patients.
To cite this abstract in AMA style:
S. Jo, KW. Park, N. Choi, CS. Lee, MS. Kim. Cerebellar involvement in progressive supranuclear palsy and corticobasal degeneration [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/cerebellar-involvement-in-progressive-supranuclear-palsy-and-corticobasal-degeneration/. Accessed June 15, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/cerebellar-involvement-in-progressive-supranuclear-palsy-and-corticobasal-degeneration/