Session Information
Date: Tuesday, September 24, 2019
Session Title: Parkinsonisms and Parkinson-Plus
Session Time: 1:45pm-3:15pm
Location: Agora 3 West, Level 3
Objective: To compare clinical characteristics in right side onset versus left side onset of Parkinson’s disease and evaluate whether side of onset was predictive of the subsequent progression of clinical symptoms.
Background: It is reported that motor deficit, quality of life and cognitive impairment in patients with right side onset PD (RPD) more severe than those in patients with left onset PD (LPD).
Method: 73 patients with PD in according to criteria of the UKBBPD have been enrolled. The patients were assessed using Hoehn and Yahr stage, UPDRS II and III parts, Mini Mental Status Examination (MMSE), de Boer’s quality of life (QOL) questionnaire, and Modified Beck Depression Inventory (BDI).
Results: Total 73 patients: 30 male (41.1%) and 43 female (58.9%) were included. 40 ROPD (54.8%) patients (mean age, 66.39 yrs; mean duration of PD, 4.36 yrs) were matched with 33 LOPD (45.2%) patients (mean age, 66.31 yrs; mean duration of PD, 3.29 yrs). SPSS Nonparametric Kruskal Wallis test revealed that ROPD patients had longer duration of disease (p<0.05), less severe rigidity symptoms on UPDRS III (p<0.005), higher score on de Boer’s quality of life questionnaire (p<0.001), and was taken higher dose L-dopa (p<0.05) than LOPD patients. In contrast, there were no significant differences in akinesia, tremor subscore on UPDRS, cognitive function on MMSE, and depressive disorder in BDI. Quality of life on de Boer’s quality of life (QOL) questionnaire was better in ROPD due to subscore in parkinsonism (p<0.005), emotion (p<0.05) and social problem (p<0.05).
Conclusion: Our results suggest that the side of onset of motor impairment significantly influence on the quality of life PD patients. Quality of life was better in patients with right onset PD than in left onset PD patients. Patients with right onset PD had longer duration of disease, was taken higher dose of L- dopa. Therefore, the initial side of parkinsonism might be predicts of quality of life in PD.
To cite this abstract in AMA style:
B. Tserensodnom. Clinical comparison of right onset PD vs left onset PD [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/clinical-comparison-of-right-onset-pd-vs-left-onset-pd/. Accessed June 15, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/clinical-comparison-of-right-onset-pd-vs-left-onset-pd/