Session Information
Date: Wednesday, June 7, 2017
Session Title: Parkinson's Disease: Cognition
Session Time: 1:15pm-2:45pm
Location: Exhibit Hall C
Objective:
To develop and validate an alternative form of the PD-CRS (PD-CRS/AF) with the objective of providing a reliable and fully equivalent method of reassessment on consecutive visits.
Background: The Parkinson’s Disease-Cognitive Rating Scale (PD-CRS) is a valid and reliable instrument to screen for and diagnose mild cognitive impairment in PD (PD-MCI) and to monitor potential outcomes in clinical trials. Although this scale shows adequate sensitivity to change in non-demented PD patients, an alternative form (AF) with proven reliability could minimize practice effects associated with repeated testing.
Methods: We selected PD-CRS/AF items following the criteria proposed in the original PD-CRS. We assessed a prospective sample of 75 non-demented PD patients (normal cognition, n = 50; PD-MCI, n = 25) using both tools, administered on two consecutive days, in a randomized order.
Results: The intra-class correlation coefficients of the total score (.96; p = 0.76) and each sub-score of the PD-CRS/AF showed a strong concurrent validity with each equivalent score of the PD-CRS. Differences between total mean scores were not significant. Floor/ceiling effects were acceptable. The discriminative power for MCI was high for both tools (area under the curve 0.91; 95% CI, 0.84-0.98 for PD-CRS; 0.88, 95% CI, 0.80-0.96 for PD-CRS/AF). Receiver operating curve analysis showed the optimal cut-off point of the two versions to discriminate PD-MCI from PD-normal cognition was ≤ 81 (PD-CRS = sensitivity 94%, specificity 73%; PD-CRS/AF = sensitivity 94%, specificity 73%).
Conclusions: Our results suggest that the PD-CRS/AF is a valid and reliable instrument to complement the original PD-CRS as an analogous tool for serial cognitive testing for PD patients in clinical practice and cognitive trials.
References: Pagonabarraga J, Kulisevsky J, Llebaria G, Garcia-Sanchez C, Pascual-Sedano B, Gironell A. Parkinson’s disease-cognitive rating scale: a new cognitive scale specific for Parkinson’s disease. Movement disorders : official journal of the Movement Disorder Society. 2008;23:998-1005 Fernandez de Bobadilla R, Pagonabarraga J, Martinez-Horta S, Pascual-Sedano B, Campolongo A, Kulisevsky J. Parkinson’s disease-cognitive rating scale: psychometrics for mild cognitive impairment. Movement disorders : official journal of the Movement Disorder Society. 2013;28:1376-83
To cite this abstract in AMA style:
R. Fernandez-Bobadilla, S. Martinez-Horta, J. Marin-Lahoz, A. Horta-Barba, J. Pagonabarraga, J. Kulisevsky. Development and validation of an alternative version of the Parkinson’s Disease-Cognitive Rating Scale [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/development-and-validation-of-an-alternative-version-of-the-parkinsons-disease-cognitive-rating-scale/. Accessed June 14, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/development-and-validation-of-an-alternative-version-of-the-parkinsons-disease-cognitive-rating-scale/