Category: Parkinson's Disease: Non-Motor Symptoms
Objective: The purpose of this study was to identify factors associated with health-related quality of life (HRQoL) in people with Parkinson’s Disease (PwP).
Background: HRQoL in PwP can be impacted by various aspects of the disease. Identifying significant predictors of HRQoL can help to effectively address the needs of those living with this condition.
Method: Parkinson’s Real-world Impact Assessment (PRISM) was an observational, cross-sectional study conducted in six European countries in which 861 PwP completed an online survey. Sociodemographic characteristics, information related to Parkinson’s disease and impact of the disease in different aspects of life were collected using a structured questionnaire. Non-motor symptoms (NMS) and impulse control behaviors (ICB) were evaluated using standardized questionnaires, and sexual function was evaluated using the Medical Outcomes Study Sexual Functioning Scale (MOS-SFS). HRQoL was assessed using the Parkinson’s Disease Quality of Life Questionnaire (PDQ-39). Stepwise multiple linear regression was used to identify factors associated with HRQoL.
Results: The mean age of the study population was 65 years and 50.6% were male. The mean PDQ-39 summary score was 32.1, with the highest scores in bodily discomfort (42.9), mobility (39.4), and emotional well-being (37.9). The total PDQ-39 score was most negatively impacted by delusions, sadness, difficulty of staying awake during activities, swallowing difficulties, and a reduction of time spent in daily activities during the previous year.
Conclusion: Addressing NMS and promoting engagement in daily activities may be important for maintaining and improving HRQoL in PwP. Further research is needed to confirm these findings and to develop effective interventions targeting NMS and involving PwP in daily activities to improve HRQoL in this population.
Study supported by Bial – Portela & CIA, S.A.
To cite this abstract in AMA style:
C. Painous, I. Pijuan, E. Tolosa. Drivers of Health-Related Quality of Life in Parkinson’s Disease: non-motor symptoms and time spent in daily activities [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/drivers-of-health-related-quality-of-life-in-parkinsons-disease-non-motor-symptoms-and-time-spent-in-daily-activities/. Accessed June 14, 2025.« Back to 2023 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/drivers-of-health-related-quality-of-life-in-parkinsons-disease-non-motor-symptoms-and-time-spent-in-daily-activities/