Objective: This study aims to develop a cost-effective, portable electrochemical sensor for real-time L-dopa monitoring in PD patients, addressing the limitations of current detection techniques.

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by significant motor and non-motor symptoms, primarily due to the depletion of dopamine-producing neurons. Levodopa (L-dopa) remains the most effective treatment, but its long-term use is associated with motor fluctuations and adverse effects, necessitating continuous monitoring of its levels. Conventional detection methods such as high-performance liquid chromatography (HPLC) and mass spectrometry, are highly precise but impractical for routine point-of-care (POC) applications due to cost, complexity, and equipment size.

Method: The sensor was fabricated using nanomaterial-based electrodes to enhance sensitivity and specificity. Characterization was performed using Cyclic Voltammetry (CV), while L-dopa detection efficiency was evaluated through Differential Pulse Voltammetry (DPV) in phosphate-buffered saline.

Results: The developed electrochemical sensor demonstrated robust material properties and achieved a detection limit of 10 nM, indicating high sensitivity. The compact and user-friendly design supports real-time monitoring, making it suitable for clinical applications.

Conclusion: This study highlights the potential of electrochemical sensors as a promising alternative for L-dopa monitoring, offering a cost-effective, sensitive, and portable solution for optimizing PD treatment. Future research will focus on clinical validation and integration into wearable POC devices for enhanced disease management.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/electrochemical-sensing-for-accurate-l-dopa-detection-in-parkinsons-disease/