MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

MENU 
  • Home
  • Meetings Archive
    • 2024 International Congress
    • 2023 International Congress
    • 2022 International Congress
    • MDS Virtual Congress 2021
    • MDS Virtual Congress 2020
    • 2019 International Congress
    • 2018 International Congress
    • 2017 International Congress
    • 2016 International Congress
  • Keyword Index
  • Resources
  • Advanced Search

Estimating the Meaningful Within-Patient Change Threshold for the MDS-UPDRS Part III

S. Zanigni, D. Trundell, A. Monnet, N. Shariati, E. Moore, E. Davies, N. Pross, G. Pagano, T. Nikolcheva (Basel, Switzerland)

Meeting: 2022 International Congress

Abstract Number: 889

Keywords: Interventions, Parkinson’s, Scales

Category: Rating Scales

Objective: To estimate the meaningful within-patient worsening threshold (MWPWT) of the Movement Disorders Society–Unified Parkinson’s Disease Rating Scale (MDS-UPDRS Part III in early-stage Parkinson’s disease (PD).

Background: In clinical research, MDS-UPDRS Part III is typically used to compare populations via a mean change from baseline score comparison. Although such a metric is useful for overall population comparison, it does not provide sufficient information on the individual experience of motor progression where a threshold of change on MDS-UPDRS Part III is required. This threshold is useful for clinical monitoring of individual patients and understanding differences in the proportion of patients experiencing motor progression in a clinical trial; it is also necessary for defining the event in a time-to-motor progression endpoint.

Method: Data were used (N=316; OFF state for MDS-UPDRS Part III) from the Phase II PASADENA study (NCT03100149). The Clinical Global Impression-Improvement (CGI-I was selected as the anchor. Spearman correlations between change from baseline scores for MDS-UPDRS Part III and CGI-I were conducted at Weeks 24 and 52. Empirical cumulative distribution function (eCDF curves for change in MDS-UPDRS Part III scores were plotted for each of the CGI-I response categories at Weeks 24 and 52. To estimate the MWPWT, the mean and median MDS-UPDRS Part III scores were calculated using data from the first visit at which individuals were rated as “Minimally worse” on the CGI-I.

Results: Correlations of 0.31–0.32 and separation of eCDF curves were identified, supporting the use of CGI-I as an anchor. Overall, 251 patients had a CGI-I rating of “Minimally worse” at a post-baseline visit, for whom a mean (median) value of 4.98 (5.00) points on MDS-UPDRS Part III was identified. This supports a MWPWT of 5 points.

Conclusion: These findings indicate that a 5-point increase on MDS-UPDRS Part III can be used as a threshold for meaningful worsening of motor signs. This supports the use of time-to-5-point increase on MDS-UPDRS Part III as the primary endpoint for the Phase IIb PADOVA study, an ongoing randomised, double-blind, placebo-controlled study evaluating the efficacy of prasinezumab in early-stage PD (NCT04777331).

To cite this abstract in AMA style:

S. Zanigni, D. Trundell, A. Monnet, N. Shariati, E. Moore, E. Davies, N. Pross, G. Pagano, T. Nikolcheva. Estimating the Meaningful Within-Patient Change Threshold for the MDS-UPDRS Part III [abstract]. Mov Disord. 2022; 37 (suppl 2). https://www.mdsabstracts.org/abstract/estimating-the-meaningful-within-patient-change-threshold-for-the-mds-updrs-part-iii/. Accessed June 21, 2025.
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2022 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/estimating-the-meaningful-within-patient-change-threshold-for-the-mds-updrs-part-iii/

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • Life expectancy with and without Parkinson’s disease in the general population
  • #25676 (not found)
  • What is the appropriate sleep position for Parkinson's disease patients with orthostatic hypotension in the morning?
  • Increased Risks of Botulinum Toxin Injection in Patients with Hypermobility Ehlers Danlos Syndrome: A Case Series
    • Effect of marijuana on Essential Tremor: A case report
    • Estimation of the 2020 Global Population of Parkinson’s Disease (PD)
    • Help & Support
    • About Us
    • Cookies & Privacy
    • Wiley Job Network
    • Terms & Conditions
    • Advertisers & Agents
    Copyright © 2025 International Parkinson and Movement Disorder Society. All Rights Reserved.
    Wiley