Session Information
Date: Wednesday, September 25, 2019
Session Title: Neuroimaging
Session Time: 1:15pm-2:45pm
Location: Les Muses Terrace, Level 3
Objective: the purpose of the study was to evaluate the possibilities of functional MRI in children with cerebral palsy in epilepsy.
Background: Magnetic resonance spectroscopy (MR-spectroscopy) makes it possible to non-invasively obtain information about metabolic changes in the brain. By comparing the relative concentrations of metabolites in the studied areas of the brain, it is possible to assess the viability and energy metabolism of the nervous tissue, proliferation and destruction of cell membranes, necrotic transformation of the brain.
Method: We analyzed the data of MRI studies among 60 children with symptomatic epilepsy with cerebral palsy, The age of children ranged from 1 to 18 years. For the quantitative and qualitative analysis of the peaks of the main metabolites such as N-acetyl aspartate (NAA), creatinine (Cr), choline (Cho), lactate (Lac) was carried out in various areas of interest. To interpret the MR spectroscopy, metabolites were evaluated quantitatively and qualitatively.
Results: During spectral analysis (frontal and temporal lobes), the following changes in the peaks of the main metabolites were established. A marked increase in choline level was noted with a moderate decrease in the concentration of N-acetyaspartate (NAA) and a decrease in the concentration ratio NAA / Cho to 0.45. Creatinine concentration remained within the normal range. They also determined a pronounced increase in the concentration of myo-inositol, with an increase in the ratio of ml / Cr to 0.65. N-acetyaspartate (NAA) has a higher concentration in the cortex of the hemispheres and the basal nuclei compared with the white matter.
Conclusion: Thus, 1H-MR spectroscopy provides fundamentally new metabolic information on the state of the white matter of the brain, in addition to the anatomical information obtained in a standard MR study. A comprehensive study of the structural and functional methods of neuroimaging allows physicians to non-invasively identify and identify microstructural disorders at the metabolic level that may be associated with epileptogenesis in child cerebral palsy.
To cite this abstract in AMA style:
D. Aminova, K. Aminov. Functional magnetic-resonant imaging in child cerebral palsy with epilepsy [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/functional-magnetic-resonant-imaging-in-child-cerebral-palsy-with-epilepsy/. Accessed June 14, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/functional-magnetic-resonant-imaging-in-child-cerebral-palsy-with-epilepsy/