Objective: To investigate the hardware-related infection frequency associated with implantable pulse generator ( IPG ) replacement in Parkinson’s patients who underwent Deep Brain Stimulation ( DBS ).

Background: The frequency of hardware-related infection seen after implantable pulse generator replacement varies between centers. In this study, we investigated frequency associated with hardware-related infections seen after implantable pulse generator replacement in our center.

Methods: 57 Parkinson’s patients with DBS who underwent IPG replacement at our center between 2007-2017 were retrospectively screened.

Results: 57 Parkinson’s patients underwent IPG replacement between 2007 and 2017 in our centre ( Ege University Medcal Faculty / Izmir- Turkey ). 23 of the patients were female and 34 were male. Forty-one of the patients were treated with Subthalamic Nucleus – DBS ( 16 female, 25 male ). Twenty-six of the patients underwent Globus Pallidus İnternus – DBS ( 7 female, 9 male ). A total of 81 IPG replacement were applied ( 29 female, 52 male ). More than one IPG change was applied to 18 patients ( 7 female, 11 male ). Average IPG replacement time in male patients 3.7 years ( 2-5 ) and 3.5 years for women ( 2-6 ). There were only 5 infections in 81 IPG replacement operations. These 5 infections occurred in 3 cases. Repeated infection occurred 2 times in 2 cases. In all cases, the infection sites were IPG place. In all cases, causative pathogens were Staphylococcus aureus. Although infections were treated with appropriate antibiotics, 2 cases had to undergo explanation. These 2 cases were 2 with recurrent infection.

Conclusions: Recurrent infections that occur after IPG replacement can cause IPG loss.

References: 1. Bhatia S, Zhang K, Oh M, Angle C, Whiting D: Infections and hardware salvage after deep brain stimulation surgery: a single-center study and review of the literature. Stereotact Funct Neurosurg 88:147–155, 2010. 2. Boviatsis EJ, Stavrinou LC, Themistocleous M, Kouyialis AT, Sakas DE: Surgical and hardware complications of deep brain stimulation. A seven-year experience and review of the literature. Acta Neurochir (Wien) 152:2053–2062, 2010.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/hardware-related-infections-seen-after-implantable-pulse-generator-replacement-in-parkinsons-patients-who-underwent-deep-brain-stimulation-a-single-center-experience/