Objective: Evaluate patient satisfaction with botulinum neurotoxin-A (BoNT-A) treatment over an injection cycle in routine practice.

Background: Benefits of BoNT-A injection in cervical dystonia (CD) typically peak within the first 2-3 wks, and then gradually wear-off over the next several weeks. This may impact patient satisfaction with treatment.

Methods: INTEREST IN CD2 is an ongoing study of CD patients treated with BoNT-A. All subjects in this baseline data analysis had previously been treated with BoNT-A. Subjects rated satisfaction with previous BoNT-A treatment in 2 ways: (1) “Today satisfaction”, which assessed satisfaction on the day of the 1st study injection (i.e. at end of previous treatment cycle) and (2) “Highest satisfaction” where subjects rated their highest level of satisfaction at any time since the last injection (i.e. peak effect).

Results: Of the 1050 subjects enrolled, 910 were previously treated with BoNT-A. Of these, 67% were female; mean age was 55.3±12.8 yrs and median time since diagnosis was 7.0 yrs. Most (64%) subjects had previously been injected with abobotulinumtoxinA, 28% with onabotulinumtoxinA and 7% with incobotulinumtoxinA (median doses 500U, 150U and 190U respectively). Less than 1% had been treated with other BoNT-A. Median time from starting BoNT treatment was 67 months and median time since last injection was 3.6 months. The median interval between injection visits was 120 days; 49% subjects had an injection interval >16 weeks, 48% between 12–16 weeks and 2% <12 weeks. Mean baseline TWSTRS scores were: Total 31.4±13.1, Severity: 15.9±5.8, Disability 9.3±6.2 and Pain 6.2±4.9. While 85% subjects reported they had been completely/rather satisfied with treatment at peak effect during their previous treatment cycle, fewer subjects (51%) reported satisfaction at the end of the treatment cycle. Interestingly, similar results were seen for subjects with a previous interval of >16 weeks (85% highest satisfaction, 50% today satisfaction) and for subjects with intervals of 12-16 weeks (85% highest satisfaction, 52% today satisfaction).

Conclusions: Patient satisfaction with the ongoing effect of BoNT-A changes over the course of a treatment cycle, however within the context of routine practice, the duration of interval between injections appears to have limited impact upon satisfaction levels.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/how-satisfied-are-cervical-dystonia-patients-with-their-botulinum-toxin-treatment-findings-from-an-international-observational-study/