Objective:

to study  the development of restless legs syndrome in advanced stage of migraine.

Background: Restless legs syndrome is relatively rare sensorimotor disorder, characterized by extremely unpleasant sensations in legs. These sensations may be worse in night, or just in rest, and subside by wiggling feet. One of the causes of restless legs syndrome is a migraine. 

Methods:

Investigated 228 (100%) patients with complicated forms of migraine, out of them, 34 (14.9%) patients suffered with restless legs syndrome. Among them in 1-group included patients  with migraine status  14 (41.2%),  in 2-group patients with chronic migraine 20 (58.8%), aged from 24 to 45 years, the average age of the patients was 41 ± 2,8 years. The analysis of clinical data was held, IRLS (Rating Scale use the scale) was used, which includes 10 questions on a 5-point scale (0-4), which allows to evaluate the intensity and frequency of manifestations of RLS, polysomnography (PSG), electroneuromyography (ENMG).

Results: Tingling, feeling of fullness, “pins and needles” and a burning sensation in the legs was observed in 11 (78.6%) patients in 1 group and 18 (90%) patients in 2 group, which emerged in rest and disappeared during active movements. In 4(28.6%) of patients of 1-group and 6 (30%) patients of 2 group, these changes were observed in the thigh, in 2 (14.3%) patients of 1 group, 4 (20%) patients of 2 group sensory impairments observed at hands. Most patients were forced to walk at night, or move the legs in the bed, leading to sleep disturbances in 10 (71.4%) patients, 15 (75%) patients, of 1 and 2 group relatively.In assessing the IRLS Rating Scale, in patients of 1group had mild (4-10 points) RLS  in 2 (14.3%) patients, moderate (11-20 points) in 5 (35.7%), severe (21-30 points) in 6 (42.9%), very heavy (30-40 points) in 1 (7.14%) patients, with those severe and very severe degree of RLS in patients of 1 group was observed in resistant migraine status. In 2 group, mild RLS was noted in 4 (20%) patients, moderate in 9 (45%), severe in 5 (25%), and very heavy in 2 (10%) patients. 

Conclusions:

Thus, RLS can often occur in classical and complicated forms of migraine, and this is a major cause of insomnia, maladjustment and depression, as well as a negative impact on the development of complicated forms of migraine symptoms.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/manifestations-of-restless-legs-syndrome-and-its-influence-on-the-clinical-course-of-associated-migraine/