Objective: 1)To evaluate the imaging manifestations of monoamine changes in PD patients with depression through 18F-FP-DTBZ PET; 2) To explore the relationship between monoamine changes and quality of life in PD

Background: Depression was one of the most common non-motor symptoms of Parkinson’s disease (PD). Dopamine, serotonin and noradrenaline system in the brain had been proven separately to be associated with depression in PD patients, while the association between total monoamine and depression was not studied. The use of monoamine-B inhibitor was linked with better resilience and mode

Method: This study included twenty six PD participants and eighteen healthy participants. According to the discriminating threshold score of HAMD-24 for depression, PD patients scored > 7 points were categorized into depressed PD （dPD） group, and others in the non-depressed PD group. After injection of 222 MBq 18F-FP-DTBZ intravenously and a 90-min quiet rest, a single frame PET(hybrid 3.0-T PET/MR) scan was acquired

Results: dPD patients showed significantly higher scores in HAMD-24 (P<0.001), HAMA (P<0.001), RBDQ-HK (P=0.045) and PDQ-39 (P=0.018) comparing to the PD group. The decrease of SUVRs values was significantly more severe in dPD than that of PD in ADP, AVP and NAc regions(*P = 0.032,*P = 0.004, *P= 0.002).HAMA score was negatively correlated with SUVRs values in ADP, AVP, PVP and NAc (P=0.031, r=-0.423; P=0.004, r=-0.551; P=0.02, r=-0.455; P=0.002, r=-0.570) ; while HAMD-24 score was negatively correlated with the values of SUVRs in AVP and NAc (P=0.01, r=-0.497; P=0.008, r=-0.508). The daily life quality of PD patients showed by PDQ-39 scores was negatively correlated with the SUVRs values in Snigra, ADP, AVP, PDP and PVP regions (P=0.014, r=-0.497; P=0.011, r=-0.512; P=0.008, r=-0.529; P=0.007, r=-0.534; P=0.007, r=-0.534)

Conclusion: The quality of life and symptoms of RBD were worse in PD patients with depression .Depression, anxiety and PDQ39 were negatively correlated with monoaminergic disruption in limbic and associative striatum subregions . Depression was also negatively correlated with monoamine loss in the NAc region despite similar severity of motor symptoms between the two groups. The results suggested that the monoamine level as a whole in the brain of PD patients may be critical for the daily management of PD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/monoamine-loss-and-depression-in-parkinsons-disease-a-pet-study/