Objective: This meta-analysis aims to assess the effect of non-pharmacological treatments for depression in patients with PD.
Background: Antidepressants are the mainstay of treatment for depression in general, as well as depression in the context of Parkinson’s disease (PD). Yet, some recent studies report that medication might aggravate motor symptoms in PD patients.
Method: Only randomized controlled trials (RCTs) were included. The participants were PD patients with comorbid depression (dPD). The interventions had the equivalent effect of non-pharmacological treatments alone compared with control(s). Scores of depression scale were selected as the primary outcome, while scores of Unified Parkinson’s Disease Rating Scale part III and the incidence of side effects were the secondary outcome. The statistics were pooled and presented as weighted mean differences (WMDs), standardized mean differences (SMDs), or risk ratios (RRs) with their 95% confidence intervals (CIs).
Results: Fifteen articles were eventually included; twelve studies reported on repetitive transcranial magnetic stimulation (rTMS) and three used cognitive behavioral therapy (CBT). Other interventions failed to have qualified studies. Our data indicated that both rTMS and CBT could significantly improve depression scores in a short term (SMD = -0.621, 95% CI [-0.964, -0.278]; SMD = -1.148, 95% CI [-1.498, -0.798], respectively). In addition, rTMS could alleviate motor symptom (WMD = -2.617, 95% CI [-4.183, -1.051]) and was relatively safe (RR = 1.054, 95% CI [0.698, 1.592]).
Conclusion: Our data suggest that rTMS can safely alleviate depression and motor symptoms in dPD at least for a short period. Moreover, compared with clinical monitoring, CBT can improve depressive symptoms. Our data suggest that rTMS can safely alleviate depression and motor symptoms in dPD at least for a short period. Moreover, compared with clinical monitoring, CBT can improve depressive symptoms.
To cite this abstract in AMA style:
J.N Chen, P.K He, Y.H Zhang, YY. Gao, Y.H Qiu, Y. Li, Q.X Zhang, L.M Wang, J.H Zhao, K. Nie, L.J Wang. Non-pharmacological Treatment for Parkinson’s Disease Patients with Depression: A Meta-analysis of Repetitive Transcranial Magnetic Stimulation and Cognitive-Behavioral Treatment [abstract]. Mov Disord. 2020; 35 (suppl 1). https://www.mdsabstracts.org/abstract/non-pharmacological-treatment-for-parkinsons-disease-patients-with-depression-a-meta-analysis-of-repetitive-transcranial-magnetic-stimulation-and-cognitive-behavioral-treatment/. Accessed June 15, 2025.« Back to MDS Virtual Congress 2020
MDS Abstracts - https://www.mdsabstracts.org/abstract/non-pharmacological-treatment-for-parkinsons-disease-patients-with-depression-a-meta-analysis-of-repetitive-transcranial-magnetic-stimulation-and-cognitive-behavioral-treatment/