Session Information
Date: Monday, June 20, 2016
Session Title: Parkinsonism, MSA, PSP (secondary and parkinsonism-plus)
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: The aim of the study is to establish chitotriosidase and oxysterols as a biomarker for atypical Parkinsonian syndromes in order to make a distinction between the various diseases possible and to be able to make a statement about the course or the severity of the diseases. In addition, undetected Niemann Pick type C patient should be identified in this population.
Background: Many neurodegenerative diseases, in particular atypical Parkinsonian syndromes, are difficult to distinguish due to their clinical presentation. In particular, there is some overlap with the clinical phenotype of Niemann Pick type C disease. The course of this disease is challenging to assess what is connected to a great suffering for the patients.
Methods: We performed a standardized analysis of our atypical Parkinsonian patients beginning in the year 2014 up to now based on the known rating scales regarding their motor performance, behavioral dysfunction, cognitive impairment and functional disability. Blood samples of the patients were sent for analysis of chitotriosidase activity and oxysterol levels to the metabolic laboratory of Prof. Marquardt, Muenster.
Results: In our population of 27 patients sixteen patients (59 %) suffered from progressive supranuclear palsy (PSP), six (22%) from corticobasal degeneration syndrome (CBDS) and five (19%) from multiple system atrophy (MSA). Determining chitotriosidase activity and measurement of oxysterol levels did not show a statistically significant difference (p = 0.25 or p = 0.20). On the other hand a precise analysis of the largest group of patients, the PSP-patients, showed up that chitotriosidase activity correlate with the clinical course of the disease and thus to the severity of the disease whereas measured oxysterol levels correlate inverse. Thus chitotriosidase and oxysterols can be taken as meaningful biomarkers, at least in patients with PSP.
Conclusions: Our data suggest that concentrations of chitotriosidase and oxysterol may show correlations to disease in progressive supranuclear palsy. No patient with Niemann Pick type C could previously be identified.
To cite this abstract in AMA style:
M. Schuberth, G. Nübling, J. Hauer, T. Marquardt, S. Lorenzl. Oxysterol and chitotriosidase as biomarkers for atypical Parkinsonian symptoms? [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/oxysterol-and-chitotriosidase-as-biomarkers-for-atypical-parkinsonian-symptoms/. Accessed June 14, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/oxysterol-and-chitotriosidase-as-biomarkers-for-atypical-parkinsonian-symptoms/