Inhaled levodopa (LD) as a treatment for Parkinson’s disease (PD) patients in an emergency setting
Objective: To report on use of CVT-301 (inhaled LD) to treat PD patients with complicated OFF period symptoms who present to the emergency department (ED).…Physiologically-based pharmacokinetic modeling of nilotinib to determine serum, cerebrospinal fluid, and brain exposures
Objective: To construct a physiologically-based pharmacokinetic (PBPK) model for predicting nilotinib pharmacokinetics (PK) in plasma and cerebrospinal fluid (CSF); and, to compare model-predicted serum and…Effect of opicapone and entacapone on early morning-OFF pattern in Parkinson’s disease patients with motor fluctuations
Objective: To evaluate the effect of opicapone (OPC) 50 mg versus entacapone (ENT) on early morning-OFF (EMO) pattern. Background: OPC, a once-daily catechol-O-methyltransferase inhibitor, was…Effects of a next-generation neurotrophic compound in a toxin model of Parkinson’s disease
Objective: Investigate the effects of a peripherally administered novel neurotrophic compound, CMx01a, in 6-hydroxydopamine rat model of Parkinson’s disease. Background: Neurotrophic factors are promising drug…A monocentric experience of Apomorphine pump follow-up on PD patients: The Optipump Cohort
Objective: The goal of this study is to describe the factors that may have an impact on Continuous Subcutaneous Apomorphine Infusion (CSAI) therapy initiation and…Distribution of intranasal hNSCs in a mouse model of MPTP-induced Parkinson’s disease
Objective: We aimed to map the distribution of human neural stem cells (hNSCs) in the brain and peripheral tissues after intranasal administration in a mouse…Sensor-Based Gait Measurements Predict Subthalamic Deep Brain Stimulation Frequency in Parkinson’s Disease Patients – A Proof of Concept Study
Objective: To conduct a proof-of-concept study to demonstrate that objectively measured gait kinematics can predict the choice of subthalamic nucleus deep brain stimulation (STN-DBS) frequency…Identification and characterization of anti-prionic compounds that disassemble αSyn prions as a novel therapeutic approach for synucleinopathies
Objective: Stabilization of monomeric α-synuclein protein (αSyn) by transient and high-affinity binding ligands is a novel and highly innovative anti-prionic treatment strategy for synucleinopathies .…Evaluation of Advanced Parkinson’s Patients Using Levodopa Carbidopa Instestinal Gel: Results of the Aegean Region of Turkey
Objective: The aim of the present study was to evaluate the outcome of LCIG treatment in advanced PD in Aegean Region of Turkey. Background: Levodopa/carbidopa…Secondary Vascular Parkinsonism: Role of increasing levels cortisol in the cognitive impairment
Objective: Elevated cortisol levels are found in many diseases, including infectious, related to aging, depression, and associated with a depressive status. Elevated cortisol levels are…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.