Changing the ‘Game’: The Impact of ‘Serious Games’-based Cognitive Training on Cognitive Function in Parkinson’s Disease
Objective: We evaluated the impact of NeuroOrb, a novel, accessible “Serious Gaming” computerised cognitive training (CT) platform, on cognitive function, mood and quality of life…Enteric Alpha-Synuclein Pathology in Early-Onset Parkinson’s Disease and an Incidental Case in Spinocerebellar Ataxia Type 6
Objective: This study aimed to investigate Alpha-synuclein (AS) accumulation in the gastrointestinal (GI) tract of patients with early-onset PD (EOPD). Background: AS accumulation is found…Longitudinal Decline of Alanine Aminotransferase Activity in Parkinson’s Disease and Its Association with Disease Duration
Objective: To characterize longitudinal trajectories of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity and the neutrophil-to-lymphocyte ratio (NLR) in Parkinson’s disease (PD) and healthy…Electrophysiological Evaluation of Visual Hallucination in Parkinson’s Disease Psychosis
Objective: Our understanding of the psychosis in Parkinson’s disease (PDPsy) is incomplete, and standard of care treatment with antipsychotics has its limitations. Neuroimaging and histopathology in PDPsy reveal that visual hallucinations (VHs), the hallmark of psychosis in PDPsy, arise…Real-World Clinical Outcomes of Adaptive versus Continuous Deep Brain Stimulation in Early-Stage Parkinson’s Disease: A Systematic Review and Meta-Analysis of 2024-2025 Trials
Objective: To evaluate the comparative efficacy, safety, and energy efficiency of adaptive deep brain stimulation (aDBS) versus continuous deep brain stimulation (cDBS) in Parkinson’s disease…Clinical Features of Patients with an Essential Tremor–to–Parkinson’s Disease Diagnostic Trajectory
Objective: To characterize the clinical phenotype and disease course of patients with an ET-to-PD diagnostic trajectory in a tertiary-care setting. Background: The longitudinal clinical features…Targeting c-Abl/Drp1-Dependent Mitochondrial Fission: Neuroprotective Effects of Berberine Chloride in Parkinson’s Disease Models
Objective: To investigate the neuroprotective potential of berberine chloride in Parkinson’s disease (PD) by modulating pathological mitochondrial fission through c-Abl–mediated Drp1 phosphorylation using integrated bioinformatics,…Quantitative Assessment of Finger Movement Profile in a Visual-Motor Task Using a Tablet Computer: Application in Multiple System Atrophy
Objective: Building on our prior FMAS validation in Parkinson’s disease (PD), we applied this tablet-based system to quantify finger movement in multiple system atrophy (MSA)…Atypical vascular parkinsonism from a midbrain lesion with excellent dopaminergic response
Objective: To present a patient with parkinsonism resulting from an ischemic lesion in the midbrain that exhibited a favorable response to dopaminergic therapy, with anatomical…Rhythmic circular stump movements after traumatic amputation: jumping stump syndrome with rapid remission after botulinum toxin type A
Objective: To describe the clinical phenomenology and treatment response of post-traumatic jumping stump syndrome following above-knee amputation. Background: Peripherally induced movement disorders are an underrecognized…
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