Can Voice Therapy Improve Swallowing in Advanced Parkinson’s Disease? A Comparison of SPEAK OUT!® Outcomes in Patients With Deep Brain Stimulation and Medical Therapy
Objective: To evaluate a 12-session SPEAK OUT!® program's effects on swallowing in advanced PD, comparing outcomes between medication-only and DBS-treated patients. Background: Oropharyngeal dysphagia is…Temporal Interference Stimulation of Dentate Nucleus Suppressed Essential Tremor
Objective: To assess the effect of 7-session transcranial temporal interference stimulation(tTIS) targeting dentate nucleus (DN) in people with essential tremor (ET). Background: ET is a…Multi-Target Neurobiological Mechanisms of Acupuncture in Levodopa-Induced Dyskinesia: From Dopamine Stabilization to Network Plasticity Modulation
Objective: To elucidate the neurobiological mechanisms through which acupuncture may alleviate levodopa-induced dyskinesia (LID) in Parkinson’s disease (PD). Background: Levodopa-induced dyskinesia (LID) is a frequent…Development of Motor Complications in Rubral Tremor treated with Levodopa
Objective: To report the long-term outcome of a case of rubral tremor responding well to levodopa, however complicated by fluctuations and dyskinesia. Background: Rubral tremor…Video-Nystagmographic Biomarkers of Oculomotor Dysfunction in Parkinson’s Disease: Correlation With Motor Severity and Cognition
Objective: To quantitatively evaluate oculomotor dysfunction using video-nystagmography (VNG) in patients with Parkinson’s disease (PD) and determine its association with motor severity, disease duration, and…Functional Improvement Following Early GPi-DBS for Moderate-Stage Atypical KMT2B Dystonia: A Case Report in a 13-Year-Old Girl
Objective: To report clinical trajectory and functional improvement of a child with atypical KMT2B-related dystonia following bilateral GPi-DBS performed at a moderate disease stage. Background:…First Reported Experience of Dual Therapy With Deep Brain Stimulation and Foslevodopa/Foscarbidopa Subcutaneous Infusion
Objective: To describe the first evidence of dual therapy with deep brain stimulation (DBS) and foslevodopa/foscarbidopa (LDp/CDp) subcutaneous infusion treating Parkinson´s disease (PD). Background: In…Exchangeable copper as a monitoring tool in Wilson disease: lessons from a 24-month prospective cohort
Objective: To evaluate exchangeable copper (CuEXC) longitudinal kinetics and its association with clinical outcomes at 24 months in Wilson disease (WD). Background: CuEXC, reflecting the…Intrinsic Suppression of the NRF2–Ferroptosis Defense Axis Defines Selective Vulnerability of D2-Striosome Neurons in Huntington’s Disease
Objective: This study mapped baseline stress-response and cell death programs in healthy human striatal populations to identify intrinsic molecular constraints in D2-striosome neurons and their…Parkinsonism in B-Cell Maturation Antigen-Targeting CAR-T Cell Cancer Therapies
Objective: Describe parkinsonism after B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR) T-cell therapy for treatment of multiple myeloma. Background: BCMA-targeted CART-cell therapy effectively treats…
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