Neurological Wilson’s disease: another form of tauopathies?
Objective: The authors would hope to identify distribution of Tau protein within the brain of Wilson's disease patients by tau-targeted positron emission tomography (PET) tracers Background:…Homozygous PRRT2 Frameshift Mutation Presenting with Infantile Onset Seizures and Childhood Episodic Ataxia
Objective: To report a rare presentation of a homozygous PRRT2 frameshift mutation manifesting as infantile-onset seizures followed by childhood episodic gait imbalance. Background: PRRT2 mutations…Multimodal Elastography-Assisted Quantitative Evaluation Tool for Diagnosing Rigidity in Parkinson’s Disease
Objective: To investigate the feasibility of multimodal elastography for quantifying rigidity in PD and to screen for diagnostically valuable muscle indicators to construct a non-invasive…Lipid Alterations in Central Nervous System and Plasma During Early Stages of Parkinson’s Disease
Objective: To identify early lipid alterations in a progressive mouse model of Parkinson’s disease (PD) and to determine whether peripheral lipid signatures reflect lipid changes…Diet Quality and Nutrient Intake in Parkinson’s Disease: A Multicenter Study in Egypt
Objective: To compare diet quality and nutrient intake between PD patients and controls and examine associations with PD clinical features. Background: Parkinson’s disease (PD) is…Survival and Related Factors in Patients with Parkinson’s Disease : A Multicenter Prospective Cohort Study in China
Objective: To estimate mortality, standardized mortality ratios (SMRs), causes of death, and survival-related risk factors in a large, multicenter Parkinson’s disease (PD) cohort from the…Sleep Circadian Rhythms and Brain Disorders: A Large Prospective Cohort and Mendelian randomization Study
Objective: This study aims to investigate the causal relationship between disruptions in sleep circadian rhythms and the risk of seven brain disorders. Background: Disruptions in…Social Network Structure and Caregiving Experiences in South Asian Families Living with Dementia Associated with Parkinsonian Disorders
Objective: To characterize social network structure and caregiving among SA families with Parkinsonian dementia (PD) and compare them with White American (WA) caregiving networks. Background:…Chronic Vanadium Exposure Promotes Memory Impairment and Aggregation of Alpha-Synuclein, Tau and Amyloid Beta in Mouse Brain
Objective: In this study, we hypothesized that prolonged vanadium exposure may be a potential risk factor for Alzheimer's and Parkinson's diseases. Background: The interaction between…Neuromelanin-Sensitive MRI as a Marker of Clinical Severity and Disease Burden in Parkinson’s Disease
Objective: To quantify associations between neuromelanin-sensitive MRI (NM-MRI) metrics and clinical severity and cumulative disease burden markers in Parkinson’s disease (PD). Background: NM-MRI visualises neuromelanin-containing…
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