Multi-ancestry analysis of POLG variants in Parkinson’s disease
Objective: To investigate the genetic spectrum and prevalence of POLG variants in PD across diverse ancestries. Background: Variants in the polymerase gamma (POLG) gene are…Exploratory Efficacy Analysis of Tavapadon Versus MAO-B Inhibitors in People With Early Parkinson’s Disease
Objective: To evaluate the effect of tavapadon vs monoamine oxidase B inhibitors (MAO-BIs) on motor function in people with early Parkinson’s disease (PD). Background: In…Clinical Gait Traits and Cerebellar-PPN Functional Connectivity Abnormalities in Early and Moderate-to-Advanced PD with Gait Disturbance via Perceptual Technology and MRI
Objective: To investigate clinical gait characteristics and cerebellar-pedunculopontine nucleus (PPN) functional connectivity (FC) changes in early-stage and moderate-to-advanced-stage Parkinson’s disease (PD) with gait disturbance using wearable…Natural History of Sialidosis Type I: A Prospective Longitudinal Follow-Up Study of Clinical and Electrophysiological Markers
Objective: We performed a prospective analysis to determine the natural history as well as changes of electrophysiological markers in a cohort of Sialidosis type I.…Digitizing PD Rating Scales Increases Reliability and Accessibility
Objective: Eliminate intra- and inter-rater variability by using digital means for rating scales and making them accessible for all. Background: Conventional clinician-rated scales like UPDRS…Multicenter Evaluation of Automated Structural MRI-based Diagnosis for Multiple System Atrophy
Objective: This study aims to evaluate whether automated classification based on individual voxel-based morphometry (VBM) adjusting covariates (iVAC) can achieve high diagnostic accuracy for MSA…Cell-type-specific asynchronous aging acceleration across movement disorders
Objective: To quantify brain cell-type–specific biological aging across different movement disorders (MDS) and compare similarities and differences in cellular aging patterns among MDS. Background: It…Comparative Effectiveness of Tavapadon Versus Real-world Oral Standard of Care Treatments in Parkinson’s Disease With Motor Fluctuations: an Indirect Comparison Analysis
Objective: To compare clinical-trial tavapadon with real-world oral standard of care (SoC) in patients with Parkinson’s disease (PD) experiencing motor fluctuations. Background: In the phase…A case of monotherapy with intracerebroventricular anaerobic dopamine allows complete control of Parkinson’s disease symptoms
Objective: To investigate the safety and efficacy of continuous circadian and personalized intracerebroventricular (i.c.v.) administration of anaerobic dopamine (A-dopamine) in Parkinson's disease patients refractory to…Does Fall-Related Activity Avoidance Differ between people with Parkinson’s disease versus Cognitively Unimpaired Controls?
Objective: investigate whether fall-related activity avoidance differs between people with Parkinson’s disease (PD) versus cognitively unimpaired controls (CU) without any significant neurological disease. Background: Although…
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