Sex-Specific Associations Between Orthostatic Hypotension and Cerebral Hypoperfusion Injury in Parkinson’s Disease
Objective: To investigate whether the association between orthostatic blood pressure changes and structural neuroimaging markers of chronic cerebral hypoperfusion and small vessel disease differ by sex…Delayed Parkinsonism Following Japanese Encephalitis: A Case Report with Dopamine Transporter Imaging and L-dopa/DCI treatment
Objective: To report a case of Japanese encephalitis (JE) presenting with thalamic–midbrain lesions followed by delayed parkinsonism confirmed by dopamine transporter imaging. Background: JE is…A Phase 1b Study to Investigate Safety, Tolerability and Biomarker Responses of Repeated Subcutaneous Doses of HER-096 in Subjects with Parkinson’s Disease
Objective: The aim of this study was to investigate safety, tolerability and biomarker responses of repeated subcutaneous (s.c.) doses of HER-096 in subjects with Parkinson’s…Clinical Gait Traits and Cerebellar-PPN Functional Connectivity Abnormalities in Early and Moderate-to-Advanced PD with Gait Disturbance via Perceptual Technology and MRI
Objective: To investigate clinical gait characteristics and cerebellar-pedunculopontine nucleus (PPN) functional connectivity (FC) changes in early-stage and moderate-to-advanced-stage Parkinson’s disease (PD) with gait disturbance using wearable…Platelet Lipididomic and Alpha-Synuclein as Peripheral Biomarkers of Disease Progression and Risk in GBA1-Associated Parkinson’s Disease
Objective: To evaluate whether integrated platelet lipidomic and α-synuclein signatures can distinguish idiopathic Parkinson’s disease (iPD), GBA1-associated PD (GBA-PD), and GBA1 non-manifesting carriers (GBA-NMC) from…DBS Evoked Cortical Potentials Can Predict Tremor Suppression
Objective: To relate the DBS evoked cortical potential (ECP) P25 to the suppression of tremor. Background: DBS‑ECPs have been investigated in DBS of the subthalamic…Longitudinal gait changes after unilateral and bilateral MRgFUS thalamotomy in Essential Tremor
Objective: To evaluate changes in gait parameters Essential Tremor (ET) patients treated with unilateral or bilateral Magnetic Resonance-guided Focused Ultrasound (MRgFUS) thalamotomy, and to assess…Postural Sway Frequencies in Isolated REM Sleep Behavior Disorder Might Indicate Subtle Motor Impairments as Prodromal Marker of Parkinson’s Disease
Objective: In this preliminary study, we aimed to compare postural sway between individuals with early, untreated Parkinson’s disease (PD), individuals with isolated REM sleep behavior…Neurofilament Light Chain Triggers Protein Aggregation, Neurotoxicity and Gliosis in Parkinson’s Disease through p38/MK2/NF-κB/CREB1 and Nrf2/HO-1 Signalling
Objective: This research investigated the active pathogenic property of Neurofilament light chain (NfL) in contributing to PD-like pathophysiology. We aimed to elucidate these mechanisms by…Complex FGF14 Repeat Expansion in Early-Onset Parkinson’s Disease
Objective: This study describes a unique case of early-onset Parkinson’s disease (PD) linked to a complex repeat expansion at the FGF14 locus. Background: While the…
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