A Case of Progressive Cerebellar Syndrome with Ataxia as a First Sign
Objective: To present a case of paraneoplastic cerebellar degeneration whose first sign was ataxia. Background: Paraneoplastic cerebellar degeneration (PCD) is a rare autoimmune syndrome that presents…A novel pro-drug overcomes short-half life and absorption challenges and increase brain penetration of dopamine as a potential therapy for Parkinson’s disease
Objective: We developed a new small molecule drug candidate that would increase the effectiveness of dopamine delivery to the brain. We also sought to mitigate…Logopenic Aphasia After Thalamotomy in Parkinson’s Disease: A Case Report
Objective: To describe a case of acute-onset, progressive language impairment resembling PPA developing after RF thalamotomy in a patient with PD. Background: Primary progressive aphasia…Integrating Olink Proteomics and Multimodal MRI to Reveal a Multimodal Signature of Parkinson’s Disease with REM Sleep Behavior Disorder
Objective: To define the distinct multimodal biomarker profile of Parkinson’s disease with rapid eye movement sleep behavior disorder (PD-RBD) by integrating clinical data, Olink-based plasma…A Retrospective Comparison of Multiple Approaches to LFP-guided and Imaging Guided Contact Selection in Subthalamic Deep Brain Stimulation for Parkinson’s Disease
Objective: To retrospectively compare several local field potential (LFP)-guided approaches for contact selection with an imaging-guided strategy and monopolar reviews, using long-term motor outcome as…Objective Parkinson’s Diagnosis Using a Novel Accelerometer Assessment and Machine Learning
Objective: To evaluate a novel motor assessment using a handheld accelerometer and machine learning to objectively support Parkinson's disease (PD) diagnosis. Background: PD diagnosis is…Barriers to Disease-Modifying Clinical Trials in Parkinson’s Disease: A Survey of Clinicians and Researchers Involved in Clinical Trials
Objective: To assess clinician and researcher views on the integration of biomarkers and biological subtyping in PD trials and perceived barriers to recruitment and completion.…Identification of Candidate Cerebrospinal Fluid Biomarkers in Multiple System Atrophy Using Mass Spectrometry‑Based Proteomics in CSF Biobank Samples
Objective: The aim of this study was to identify additional new biomarkers using mass spectrometry-based proteomics in well-defined clinical samples from a phase II clinical…Peripheral neuropathy (NP) in advanced Parkinson’s disease (PD) patients treated with continuous subcutaneous foslevodopa/foscarbidopa (fLD/fCD)
Objective: To assess peripheral NP occurrence and clinico-electrophysiological features in patients with advanced PD patients treated with continuous subcutaneous fLD/fCD. Background: Continuous subcutaneous fLD/fCD is effective…Levodopa dosing regimen influences repetitive tongue force maintenance in Parkinson’s disease
Objective: To investigate whether levodopa (LD) dosing regimen influences the dynamics of repetitive maximal tongue pressure (MTP) in patients with Parkinson’s disease (PD). Background: Reduced…
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