Objective Parkinson’s Diagnosis Using a Novel Accelerometer Assessment and Machine Learning
Objective: To evaluate a novel motor assessment using a handheld accelerometer and machine learning to objectively support Parkinson's disease (PD) diagnosis. Background: PD diagnosis is…Axonal-demyelinating polyneuropathy after subcutaneous foslevodopa/foscarbidopa infusion – case report.
Objective: The aim of this report was to present a patient with Parkinson’s disease (PD) treated with continuous subcutaneous foslevodopa/foscarbidopa infusion (CSFLI) who developed axonal-demyelinating…Untangling the Web of Fall Risk in Parkinson’s Disease Through Machine Learning
Objective: to use machine learning on detailed clinical, cognitive, balance, and gait data to identify which features best predict falls risk in people with Parkinson’s…Reframing Treatment Paradigms: The Rise of Cell and Gene Therapies in Parkinson’s Disease
Objective: To characterize the global clinical landscape and temporal evolution of disease modifying cell and gene therapy trials in Parkinson's disease (PD), including modality distribution,…Basal ganglia and cerebellum involvement in Myelin Oligodendrocyte antibody associated disease (MOGAD) presenting with facial Dystonia and limb Tremer
Objective: Movement disorder in MOGAD is rarely reported in literature. Here we report a case of female with facial dystonia and tremor a rare manifestation.…Synergistic Impact of Plasma Neurofilament Light Chain and Neuroimaging Deficits on Cognitive Decline in Prodromal Lewy Body Disease
Objective: To assess the synergy between neuroimaging deficits and plasma biomarkers in predicting longitudinal cognitive and motor progression in individuals at high risk for prodromal…The Parkinson’s Impact Project: A Multimodal Longitudinal Study of Disease Development and Progression at the 23andMe Research Institute
Objective: Characterize the interactions between lifestyle, environmental, and genetic exposures on susceptibility to Parkinson’s disease (PD) and progression rates through a scalable remote web-based multimodal…GBA1 deficiency promotes tau and TDP-43 co-pathology
Objective: To determine whether mutations in the gene beta-glucocerebrosidase 1 (GBA1), the strongest genetic risk factor for PD, promote tau and TDP-43 co-pathology alongside Lewy…Quantitative Changes in Speech After Focused Ultrasound Thalamotomy in Parkinson’s Disease and Essential Tremor
Objective: To compare speech performance following unilateral MR-guided focused ultrasound (MRgFUS) targeting the ventral intermediate nucleus (VIM) of the thalamus in Parkinson’s disease (PD) and…Prevalence and neuroimaging presentations of Parkinsonism patients with p.R544C NOTCH3 mutation in Taiwan
Objective: To investigate the prevalence and neuroimaging findings of NOTCH3 p.R544C mutation in patients with Parkinsonism in Taiwan. Background: Cerebral autosomal dominant arteriopathy with subcortical…
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