Clinical Outcomes of Deep Brain Stimulation in Malaysian Children with Pharmacoresistant Dystonia
Objective: To evaluate the clinical outcomes of deep brain stimulation (DBS) in Malaysian children with pharmacoresistant dystonia. Background: Dystonia is a common paediatric movement disorder…Postural Stability After CSF Drainage in Idiopathic Normal Pressure Hydrocephalus: Association with Gait Response
Objective: To examine changes in postural stability after CSF drainage using center of pressure (COP) analysis and their association with gait response in patients with…Speech And Gait In Newly Diagnosed Parkinson’s Disease: Support For Early Rehabilitation
Objective: To describe the prevalence of self-reported speech difficulties in newly diagnosed Parkinson’s disease (PD) and to explore its associations with dysphagia, hypersalivation (HS) and…Objective Parkinson’s Diagnosis Using a Novel Accelerometer Assessment and Machine Learning
Objective: To evaluate a novel motor assessment using a handheld accelerometer and machine learning to objectively support Parkinson's disease (PD) diagnosis. Background: PD diagnosis is…Knee Extensor Strength Is Associated with Torque Generation and Mobility in Parkinsonian Disorders
Objective: To examine associations among knee extensor strength (KES), torque generation during knee extension quantified by the area under the torque–time curve (AUC), and functional…Safety of Opicapone After 10 Years of Post-Marketing experience Worldwide
Objective: To review the safety data of opicapone (OPC) after 10 years of worldwide marketing experience. Background: OPC, a third-generation COMT inhibitor, is approved as…Healthcare Resource Utilization and Costs of Multiple System Atrophy in the United States: An Observational Database Study
Objective: To assess the direct healthcare costs and healthcare resource utilization (HCRU) of MSA in the US commercially insured population. Background: MSA is a rare,…Baseline characteristics of fallers versus non-fallers in a remote, decentralized study of Parkinson’s disease
Objective: To compare the baseline characteristics of fallers versus non-fallers in a remote, decentralized study of Parkinson’s disease (PD) participants. Background: Falls are common in…Sleep disorder Clustering and Clinical Impact in Multiple System Atrophy
Objective: To characterize clustering patterns of sleep disorders in multiple system atrophy (MSA) and evaluate their clinical impact. Background: Sleep disorders are common in MSA.…First-in-Human Single-Ascending-Dose Trial of ALN-SNCA, an Intrathecally Administered siRNA for Reducing α-synuclein, in Patients with Early-Stage Parkinson’s Disease
Objective: Development of a Phase 1, First-in-Human (FIH) clinical trial evaluating ALN-SNCA, a novel, intrathecally (IT) delivered small interfering RNA (siRNA) targeting SNCA mRNA to…
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