SYN120 (a Dual 5-HT6/5-HT2A Antagonist) Study to Evaluate Safety, Tolerability and Efficacy in Parkinson’s Disease Dementia (SYNAPSE): Phase 2a Study Results
Objective: To evaluate the safety and preliminary efficacy of SYN120 in patients with Parkinson's disease dementia (PDD). Background: SYN120 is an antagonist of serotonin receptors…Integrated Complimentary Yoga and Ayurveda Treatment Confers Significant Benefits in PD Patients
Objective: The present study was carried out to evaluate the efficacy of integrated complimentary Yoga & Ayurveda treatment in improving the motor symptoms and also…A Physiotherapy Exercise Program for Parkinson’s Disease Patients with Impaired Gait and Postural Control
Objective: To improve the gait stability of Parkinson's disease(PD) patients by physiotherapy and gait skill training. Background: Current pharmacological therapy for PD is largely based…Emulating the natural timing of dopamine receptor activation in Parkinson’s Disease
Objective: To emulate physiological dopamine receptor activation, in order to restore temporal patterns of dopamine-like signalling and normalise function in the striatum in Parkinson's disease.…TreCap: Quantify and assess tremor in real-time with a new wearable device
Objective: To develop a wearable device with novel software features for real-time analysis and assessment of tremor in the clinical environment. Background: Visual examination of…Novel mechanistic involved in targeting Parkinsons Disease by Indolocarbazole derivatives as inhibitors against Cyclin Dependent kinases using molecular modelling and simulation approaches
Objective: To validate effect of Indolocarbazole derivatives on Cyclin dependent kinase for treating Parkinson's (Preliminary work in context of CDK5 assay and Simulations have been…Safinamide add-on therapy increases ON time without dyskinesia in fluctuating Parkinson’s Disease (PD) patients with moderate to severe dyskinesia
Objective: This post-hoc analysis examined safinamide efficacy for providing dyskinesia-free ON time in LID patients. Background: Safinamide has both dopaminergic and glutamate modulating activity. The…Does the effect of continuous levodopa infusion treatment for Parkinson’s disease regress as the day progresses?
Objective: The goal of this project is to examine if there is evidence to suggest that there is a difference in response to levodopa during…Efficacy and safety of safinamide as a levodopa adjunct in patients with parkinson disease and motor fluctuations: A systematic review of randomized controlled trials
Objective: To assess the efficacy and safety of safinamide as an add-on therapy to levodopa in Parkinson patients. Background: Long-term use of levodopa is associated…Efficacy of ND0612 for nocturnal problems and early morning OFF
Objective: ND012 is a drug-device combination delivering liquid L-dopa/carbidopa (LD/CD) via continuous SC infusion. This secondary analysis evaluated the efficacy of 2 dosing regimens (R1:…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.