VY-AADC01 gene therapy in Parkinson’s disease: Interim results of the on-going Phase 1b PD-1101 trial
Objective: Evaluate the safety of VY-AADC01, an AAV2 gene therapy vector with human aromatic L-amino acid decarboxylase (AADC) administered bilaterally to the putamen using intraoperative…A controlled trial of ParkinSong singing groups to improve communication and wellbeing in Parkinson’s disease
Objective: To explore the effects of a therapeutic group singing intervention (ParkinSong) on communication and wellbeing outcomes for people living with Parkinson's disease. Background: Communication…Quantitative assessment of the effectiveness of adaptive Deep Brain Stimulation in Parkinson’s disease
Objective: To determine the effectiveness of Adaptive Deep Brain Stimulation (aDBS) in PD patients compared to cDBS and non-medicated PD patients (OFF). Background: aDBS based…Closed Loop Programming Evaluation Using External Responses for Deep Brain Stimulation (CLOVER-DBS)
Objective: To assess the feasibility and efficacy of a novel closed-loop programming algorithm (CLPA) for deep brain stimulation (DBS) based on objective feedback using a…The possibility of medicamentous correction of the lower urinary tract dysfunction in patients with Parkinson’s disease
Objective: The aim of the study was to correct the dyskinesia of the extremities, to study the efficacy and safety of drug therapy in men…Development of a biomarker for Parkinson’s disease by measuring alpha-synuclein oligomers in cerebrospinal fluid with ultrasonication-induced amyloid fibril formation
Objective: To establish a new technique quantifying misfolded alpha-synuclein (αSyn) oligomers in the CSF and to investigate their clinical - pathological significances in Parkinson’s disease…Management of chronic polyneuropathy associated with levodopa-carbidopa intestinal gel infusion in Parkinson’s disease: Review of the strategies and perspectives
Objective: (1) To make an inventory of the current strategies used to treat or prevent the occurrence of chronic polyneuropathy (CPN) in patients with Parkinson’s…Switching from double-blind entacapone or placebo to open-label opicapone: NMSS results of the 1-year extension BIPARK-I study
Objective: To evaluate the impact on non-motor symptoms in levodopa-treated Parkinson’s disease (PD) patients who switched from placebo (PLC) or entacapone (ENT) to opicapone (OPC)…Long-term effect of subthalamic nucleus deep brain stimulation on freezing of gait in patients with advanced Parkinson’s disease
Objective: To investigate the long-term effect of subthalamic nucleus deep brain stimulation (STN-DBS) on freezing of gait (FOG) in patients with Parkinson's disease (PD) by…After Deep Brain Stimulation Surgery for Parkinson’s Disease risk Factors for Postoperative Delirium
Objective: The aim of this study was to investigate the incidence of and risk factors for postoperative delirium (POD) after deep brain stimulation (DBS) surgery…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.