Cerebrospinal fluid proteomics reveals alterations of the renin-angiotensin system in Huntington’s disease
Objective: To identify new biomarkers of disease stage in HD. Background: Proteomic approaches for CSF studies in Huntington’s disease (HD) have so far yielded limited…White matter microstructural alterations in Huntington Disease: When neurodegeneration starts?
Objective: The aim of our study is to characterize in detail the white matter (WM) microstructure alterations in Huntington Disease (HD) using the diffusion tensor…A randomized, double-blind, placebo-controlled Phase II Efficacy and Safety Study of the PDE10A inhibitor PF-02545920 in Huntington Disease (AMARYLLIS)
Objective: To assess efficacy on motor function, safety and tolerability of the phosphodiesterase-10A inhibitor PF-02545920 in Huntington disease (HD). Conclusion: PF-02545920 was generally safe and…Pharmacological investigation of biochemical and behavioral effects resembling Huntington’s disease utilizing selective calcium and calmodulin dependent phosphodiesterase inhibitor
Objective: To investigate the effects of selective phosphodiestrase (PDE) inhibitors in Nimodipine induced neuro degeneration (animal models of Huntington’s disease) in rats. Background: Nimodipine is…Decision making in Huntington’s disease
Objective: To investigate perceptual decision making and reflexion impulsivity in preclinical and manifest patients with Huntington’s disease (HD). Background: Huntington’s disease (HD) is an autosomal…Clinical and genetic data of Huntington disease in Uzbekistan patient
Objective: Huntington's disease (HD) occurs worldwide with prevalence varying from 0.1 to 10/100,000 depending of the ethnic origin. Since no data is available in the…Interrater reliability of the Unified Huntington’s Disease Rating Scale-Total Motor Score certification
Objective: The aim of this study was to investigate the interrater reliability of the Unified Huntington’s Disease Rating Scale-Total Motor Score (UHDRS-TMS) and of its…Speech in Huntington’s Disease
Objective: To review existing literature on speech function in Huntington’s disease (HD) across the disease spectrum. Background: Impairment in speech production affects the majority of…Parallel evaluation of mutant huntingtin and neurofilament light in Huntington’s disease
Objective: To assess cerebrospinal fluid (CSF) mutant Huntingtin (mHTT), and CSF and plasma neurofilament light (NfL) in Huntington’s disease (HD). Background: HD is a progressive…Neuronal correlates of oculomotor alterations in Huntington’s disease. A 18-FDG PET study
Objective: To explore the neuroanatomical correlates of the oculomotor abnormalities in Huntington's disease (HD) through a 18-FDG PET study Background: Alterations of the oculomotor function…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.