Late-Onset Bulbar-Predominant Neurodegeneration Associated With a Truncating AFG3L2 Variant: Expanding the Clinical Spectrum of AFG3L2-Related Disease
Objective: To describe an atypical late-onset, bulbar-predominant neurodegenerative presentation associated with a heterozygous truncating AFG3L2 variant and contextualize this phenotype within the expanding spectrum of…Association of Neurofilament Light Chain with Substantia Nigra Degeneration in Parkinson’s Disease
Objective: This study aims to investigate the association between serum neurofilament light chain (NfL), microstructural changes in the substantia nigra, and clinical manifestations in Parkinson’s…Revisiting the Association between Estrogen Exposure and Parkinson’s Disease: A Fox Insight Analysis
Objective: To evaluate the association between markers of lifetime estrogen exposure and Parkinson’s Disease (PD) in a large digital cohort of postmenopausal women. Background: The…Evaluating the Conversion of Immediate-Release and/or Extended-Release Levodopa to IPX203 in Patients with Parkinson’s Disease
Objective: This quality improvement (QI) project was conducted to evaluate the impact of the conversion from immediate-release (IR) and/or extended-release (ER) levodopa (LD) to mucoadhesive polymer…Cholinergic Basal Forebrain Atrophy Associates with Short-Latency Afferent Inhibition and Cognitive Impairment in Parkinson’s Disease
Objective: To investigate whether cholinergic basal forebrain (cBF) atrophy mediates the relationship between short-latency afferent inhibition (SAI) and cognitive performance in PD. Background: Cognitive impairment…Electrocardiographic Indicators of Autonomic Dysfunction in Parkinson’s Disease: A Scoping Review and Meta-analysis
Objective: To systematically map and quantitatively synthesize evidence on ECG-derived markers associated with autonomic dysfunction in PD and evaluate their ability to differentiate patients from…REM Sleep Behaviour Disorder and early non-motor symptoms in Parkinson’s Disease
Objective: To investigate early non-motor symptoms between the RBD-positive and RBD-negative PD patients from the Early Parkinson’s Disease Longitudinal Singapore study (PALS) cohort. Background: REM…Quantitative Neurodegenerative Risk Modelling and Clinical Score Prediction Using Mixed Reality
Objective: This study investigates the potential of mixed reality (MR) tool for multimodal data collection from individuals with Parkinson’s disease and examines the use of…Altered Motor Regulation and Limbic-Motor Circuits in Paroxysmal Kinesigenic Dyskinesia
Objective: To explore underlying circuit-level mechanisms in paroxysmal kinesigenic dyskinesia (PKD). Background: While the cortico-striato-thalamo-cortical loop and cerebellum are implicated in PKD pathophysiology, the causal…Two-year Outcomes of Rapid Eye Movement Behavior Disorder Following Globus Pallidus Interna Deep Brain Stimulation for Parkinson’s Disease
Objective: This study evaluated two-year outcomes of rapid eye movement (REM) sleep behavior disorder (RBD) in a cohort of patients with Parkinson’s disease (PD) who…
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