Spectrum of Wilson’s Disease from a Tertiary care hospital
Objective: 1. To describe the various neurological manifestations in Wilson's disease2. To describe the non-neurological manifestations in Wilson's disease Background: Wilson's disease is a rare…A Randomized Controlled Trial Evaluating Ankle Pump Combined with Compression Abdominal Belts on Orthostatic Hypotension in Patients with Parkinson’s Disease
Objective: To investigate the short-term efficacy of ankle pump exercise combined with automated compression abdominal belts on orthostatic hypotension (OH) and orthostatic intolerance symptoms in…Late-Onset Bulbar-Predominant Neurodegeneration Associated With a Truncating AFG3L2 Variant: Expanding the Clinical Spectrum of AFG3L2-Related Disease
Objective: To describe an atypical late-onset, bulbar-predominant neurodegenerative presentation associated with a heterozygous truncating AFG3L2 variant and contextualize this phenotype within the expanding spectrum of…The Diagnostic Value of Dopaminergic-Glucose United PET Imaging in Parkinson’s disease
Objective: This study aimed to evaluate the diagnostic efficacy of DAT-FDG united PET imaging in differentiating PD from other parkinsonian disorders in real-world clinical settings…Association of Neurofilament Light Chain with Substantia Nigra Degeneration in Parkinson’s Disease
Objective: This study aims to investigate the association between serum neurofilament light chain (NfL), microstructural changes in the substantia nigra, and clinical manifestations in Parkinson’s…Mild Motor Impairments in Rapid Eye Movement Behavior Disorder: Tremor and Bradykinesia
Objective: We investigated patients with RBD to identify mild motor impairments through the objective quantification of sensitive motor control assays. Background: It is established that…NIH Multicenter Consortium for Gut-Brain Communication in Parkinson’s Disease: The Master Protocol and Timeline
Objective: To describe the master protocol and timeline for the multicenter Gut-Brain Communication in Parkinson’s Disease Consortium (GBPDC), funded by NIDDK/NIH (UO1) from 2024 to…Degradation Mechanisms of PolyG
Objective: To characterize the polyglycine (polyG) interaction network and identify its degradation mechanisms. Background: polyG translated from GGC repeat expansions in the 5′UTR of NOTCH2NLC…MobilityAPP: A randomized-controlled trial evaluating gait-focused physiotherapy in Parkinson’s disease and atypical parkinsonian syndromes
Objective: Effect on gait and balance of gait-focused physiotherapy compared to standard-of-care physiotherapy in patients with MSA, PSP and PD. Background: Physiotherapy is a crucial element…Neuroimaging-guided automated optimization of deep brain stimulation in Parkinson’s disease: preliminary results
Objective: To evaluate the clinical impact of an automated neuroimaging-guided optimization algorithm (Illumina™, Boston Scientific) for programming in patients with suboptimal response to subthalamic nucleus…
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