Constipation in early de novo Parkinson’s disease: Prevalence and correlates with clinical features, imaging and non-imaging biomarkers
Objective: To explore the association between constipation and clinical features, imaging and non-imaging biomarkers in early de novo (untreated) Parkinson's disease (PD) patients. Background: Constipation…A novel C. elegans model for identification of small molecules that target alpha-synuclein-mediated toxicity
Objective: To develop a novel transgenic C. elegans model to study dopaminergic neurodegeneration mediated by alpha-synuclein. Background: Targeting alpha-synuclein could be a disease-modifying strategy for…Difference of REM sleep behavior disorder between the onset of before and after Parkinson’s disease
Objective: It is not clear that the onset of RBD (REM sleep behavior disorder) affect clinical characteristics of PD. A cross section study comparing clinical…Cell-surface expression of dopamine transporter facilitates the uptake of α-synuclein
Objective: We determined whether increased expression of DAT have an impact on the uptake of α-synuclein (αS). Background: The endocytosis of dopamine transporter (DAT) controls…Bcr-Abl tyrosine-kinase inhibitors (B-ATKI) and Parkinson’s disease (PD)
Objective: Looking through the Kaiser Permanente National Parkinson's disease Registry, generated through the electronic medical records (EMR), we took a first step in looking at…Optimization of 6-hydroxydopamine animal model of early stage Parkinson´s disease for the assessment of neurorestorative therapies
Objective: To optimize a simple unilateral partial 6-hydroxydopamine (6-OHDA) lesion protocol that would produce 40-60% striatal dopamine (DA) depletion with detectable motor deficits and to…Modulation of microglia function in the prion-like spreading of α-synuclein in the murine brain
Objective: We aimed to analyze the influence of two microglia-related pathways on the accumulation of α-synuclein aggregates and neurodegeneration after intracerebral injection of sonicated murine…Neurodegeneration and microgliosis are independent of α-synuclein aggregation in a mouse model of "prion-like" α-synuclein speading
Objective: Our aim was to test if α-synclein aggregation drives neuronal demise and microglial activation in a murine model of induced-α-synucleinopathy. Background: Pathological α-synuclein aggregates…Role of macroautophagy in regulating microglia-mediated neuroinflammation and dopaminergic neuron injury
Objective: To investigate the potential role of macroautophagy in the regulation of microglia-mediated neuroinflammation and dopamine neuron injury. Background: Chronic neuroinflammation, a process mediated by…The impact of levodopa and apomorphine on beta- and gamma-oscillations in cortico-basal ganglia circuits in experimental parkinsonism
Objective: To clarify the role of pathologic oscillations in Parkinson's disease (PD) we recorded local field potentials (LFPs) in cortico-basal ganglia circuits of Parkinsonian and…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.