Lymphocytes have a detrimental effect on motor behavior in the AAV1/2 A53T α-synuclein mouse model of Parkinson’s disease
Objective: To determine the contribution of the adaptive immune system in the pathogenesis of a mouse model of Parkinson's disease (PD) based on AAV1/2 driven…Lewy body extracts from Parkinson’s disease brains as models for high-throughput screens of neurotoxicity and α-synuclein spreading from cell-to-cell
Objective: To validate the effect of Lewy body extracts from Parkinson's disease (PD) brains in high-throughput screens of neurotoxicity and the α-synuclein (α-syn) spreading from…The contribution of the subthalamic nucleus in gait initiation of subjects with Parkinson’s disease
Objective: We investigated the contribution of the subthalamic nucleus (STN) in gait initiation of subjects with Parkinson's disease (PD). Background: Gait initiation is the transient…Parkinson’s disease motor subtypes show similar deficits in inhibitory control
Objective: To determine whether predominant motor subtypes of Parkinson's disease (PD) differentially impact distinct forms of inhibitory motor control. Background: Parkinson's disease (PD) impairs rapid…Effects of Arachidonyl-2′-chloroethylamide (ACEA), a selective CB1 receptor agonist, in MPTP mouse model of Parkinson’s disease
Objective: Cannabinoids have been demonstrated to be effective in preclinical studies involving oxidative stress, neuroinflammation, and motor complications associated with Parkinson's disease (PD).The CB1 cannabinoid…Alpha-synuclein – super-resolution microscopy reveals potential new role of alpha-synuclein at the pre-synapse
Objective: Alpha-synuclein is a major key player in Parkinson's disease, however its physiological function still remains elusive. Using super-resolution microscopy this study aims to analyse…Floor square size predicts step count of 360° turns in PD patients with freezing
Objective: To determine the effect of floor square size on turning behavior in patients with PD. Background: Turning has been repeatedly shown to be the…Differential expression of cerebral dopamine neurotrophic factor (CDNF) in the hippocampus and in the striatum of LRRK-2 mutant rat model of Parkinson’s disease
Objective: The objective of our study was to characterize the behavioral phenotype of the transgenic LRRK-2 rat in the context of PD model and to…Diffusion tensor imaging (DTI) within the primate caudate nucleus marks dopaminergic (DA) and serotonergic (5-HT) lesions
Objective: To determine the best diffusion tensor imaging markers of dopaminergic and serotonergic lesions in the non-human primate. Background: DTI has received particular interest to…Role of dopamine and GABA during subthalamic and pallidal deep brain stimulation: Evidence of dopamine release during subthalamic Deep Brain Stimulation
Objective: We recorded the single-unit activity of striatal cholinergic interneurons of healthy monkeys during high-frequency stimulation (HFS) of the subthalamic nucleus (STN) and globus pallidus…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.