Autophagic modulation by rosuvastatin prevent rotenone induced neurotoxicity as an in vitro model of Parkinson’s disease
Objective: We investigated effects of statin on autophagy markers and evaluated the neuroprotective effect of rosuvastatin from rotenone induced neurotoxicity. Background: Recently, autophagy pathway is…Targeting PDE7 by the small molecule S14: A potential disease-modifying Parkinson�s disease therapy ready to start clinical trials
Objective: The main goal of this work is the regulatory chemical, pharmaceutical and toxicological development of S14, a new therapeutic class for the potential treatment…The role and underlying mechanisms of BAG3 in regulating autophagy in PC12 cells
Objective: To detect the role of Bcl-2-associated athanogene 3 (BAG3) in regulating autophagy in PC12 cells and explore the underlying mechanisms of it. Background: Increasing…AntiParkinsonian effects of the “radiprodil and tozadenant” combination in MPTP-treated marmosets
Objective: Investigate a combination of two clinically tested drugs, the NR2B antagonist Radiprodil and the A2A antagonist Tozadenant in unilaterally 6-OHDA-lesioned rats and in MPTP-treated…Selective M4 antagonism potentiates L-DOPA-induced dyskinesia in MPTP-treated common marmosets
Objective: To determine the role of M4 muscarinic receptors in the expression of L-DOPA-induced dyskinesia (LID) and dystonia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated common marmosets. Background:…An ongoing phase 2, multi-centre, open-label, study of WTX101 in Wilson disease patients – Early observations
Objective: The aim of this ongoing study is to evaluate the efficacy and safety of WTX101 in newly diagnosed Wilson Disease patients. Background: WTX101 (bis-choline…Clinical characterization of pramipexole induced edema in Parkinson’s disease (PD). Is it always the best option discontinue the treatment?
Objective: Report a patient with PD treated with irregular doses of pramipexole and extensive chronic edema in lower extremities after 8 years of treatment, taking…The unfolded protein response pathway as a possible therapeutic target for the synucleinopathies
Objective: To investigate whether the pharmacological inhibition of unfolded protein response (UPR) pathway would be beneficial in cellular model of synucleinopathies. Background: It has been…May early introduction of dopaminergic agonists improve simptoms after ischemic stroke? The interim report
Objective: To evaluate the effect of bromocriptine on motor impairment, functional disabilit and cognitive impairment 5, 10, and 15 of bromocriptine therapy in patients with…A computational model of iron transport between the blood circulation and the brain
Objective: To create a mechanistic computational model of iron transport between the circulation and brain, permitting in silico investigation of homeostatic regulation of iron at…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.