A Brief Clinical Test Battery Predicting UPDRS II Disability in Parkinson Disease
Objective: To determine whether a brief battery of commonly used clinical performance tests can predict disability in activities of daily living measured by UPDRS II…Motor Fluctuations and Dyskinesias in LRRK2-Associated Parkinson’s Disease
Objective: To characterize motor fluctuations and dyskinesias in patients with LRRK2-associated Parkinson’s disease. Background: Motor complications, including dyskinesias and motor fluctuations, are hallmarks of advanced…GSTM1 and GSTT1 null genotypes as candidate modifiers of clinical severity and genomic instability in Cuban patients with Spinocerebellar Ataxia type 2
Objective: To assess the impact of the GSTM1 and GSTT1 null genotypes on clinical severity and genomic instability in a large cohort of patients with…Environmental Determinants of Parkinson’s Disease in Saudi Arabia: A Cross-Sectional Study
Objective: To examine environmental and socioeconomic exposures associated with Parkinson’s disease (PD) in Saudi Arabia. Background: PD is a multifactorial neurodegenerative disorder influenced by genetic…Effects of Chronic IEM-1460 Treatment on Perineuronal Net–Parvalbumin Interneuron Association in L-DOPA-Induced Dyskinesia
Objective: To determine whether chronic IEM-1460 administration alters dyskinesia and perineuronal net (PNN)–parvalbumin interneuron (PV-IN) association in a 6-OHDA rat model of L-DOPA-induced dyskinesia (LID).…Psychiatric manifestations in premanifest Huntington’s disease as early indicators of motor onset: a systematic review
Objective: To identify and analyze psychiatric manifestations acting as early indicators in individuals carrying the HTT gene mutation during the premanifest stage, evaluating their prevalence…ANK2 Mutations Associated with a Myoclonus-Dystonia Phenotype: Expanding the Neurological Spectrum of Ankyrin-B Dysfunction
Objective: To deeply characterize the clinical and genetic spectrum of ANK2-related hyperkinetic movement disorders and expand their recognized link to myoclonus-dystonia phenotype. Background: The ANK2…Revisiting Prodromal Diagnostic Criteria in MSA: The Need for Early MRI-Based Diagnosis
Objective: This prospective cohort study investigated the role of neuroimaging for the early and accurate identification of multiple system atrophy (MSA) in patients with indeterminate…Cerebellar Network Compensation in Parkinson’s Disease: Functional Connectivity Across Motor and Cognitive Circuits
Objective: To investigate whether alterations in cerebellar connectivity with cortical and basal ganglia networks in Parkinson’s disease (PD) represent compensatory network adaptations related to dopaminergic…Investigating Phospho-α-Synuclein Pathology in Patient-Specific Microglia Integrated into Midbrain Organoids
Objective: This study aims to determine how patient-specific microglia influence phospho-α‑synuclein aggregation and contribute to disease-relevant phenotypes within human midbrain organoids. Background: Parkinson’s disease (PD)…
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