Psychiatric manifestations in premanifest Huntington’s disease as early indicators of motor onset: a systematic review
Objective: To identify and analyze psychiatric manifestations acting as early indicators in individuals carrying the HTT gene mutation during the premanifest stage, evaluating their prevalence…Efficacy of Mechanoacoustic Vibration Therapy on Motor Function, Bone Density, and Sleep Architecture in Elderly Women with Restless Legs Syndrome
Objective: To evaluate the rehabilitative impact of targeted mechanoacoustic vibration therapy on mobility, bone mineral density (BMD), pain, and sleep quality in elderly women with…Effects of Chronic IEM-1460 Treatment on Perineuronal Net–Parvalbumin Interneuron Association in L-DOPA-Induced Dyskinesia
Objective: To determine whether chronic IEM-1460 administration alters dyskinesia and perineuronal net (PNN)–parvalbumin interneuron (PV-IN) association in a 6-OHDA rat model of L-DOPA-induced dyskinesia (LID).…Transcutaneous Auricular Vagus Nerve Stimulation as a Novel Therapy for Parkinson’s Disease: Meta-Analytic Evidence of Motor and Gait Effects
Objective: To evaluate the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on motor function and gait in patients with Parkinson’s disease (PD). Background: taVNS…Mechanisms of PLA2G6 Deficiency Impacting Mitochondria-associated membranes in Parkinson’s Disease
Objective: This study aims to explore the functions of PLA2G6 protein at the endoplasmic reticulum-mitochondria interface, unveiling the potential mechanisms of PLA2G6-related Parkinson’s disease (PD)…Blood glucose homeostasis is conserved in patients with mild to moderate Spinocerebellar Ataxia type 2
Objective: To explore novel molecular biomarker candidates for SCA2, based on the assessment of blood glucose homeostasis. Background: Spinocerebellar ataxia type 2 (SCA2) is a…Ambulatory prognosis in spinocerebellar ataxia type 6: a single-center cohort study
Objective: To evaluate the ambulatory prognosis and fall-related events in patients with spinocerebellar ataxia type 6 (SCA6) in a real-world clinical setting. Background: SCA6 is…The Lived Experience of Parkinson’s Disease in the Philippines: Challenges, Cultural Constructs, and Caregiving Impacts
Objective: This study aims to explore the lived experiences of PD patients and their caregivers in Cebu Province, Philippines; identify psychosocial and healthcare-related challenges; assess…Clinical Features and Trajectories Related to Entacapone Use in Parkinson’s Disease: insights from the French NS Park Cohort
Objective: This study aimed to provide real-life entacapone use in French PD expert centers, focusing on temporal trends, therapeutic positioning, and treatment persistence. Background: Optimizing…Genetic modifiers of the clinical phenotype in Spinocerebellar Ataxia type 2. 25 years of candidate genes studies and the forthcoming GWAS era
Objective: To provide a critical review the state of the art on the search for modifier genes for disease severity of SCA2. Background: Spinocerebellar ataxia…
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