Stage-Dependent Dysregulation of Peripheral TREM2, SOD1, and Neurofilament Light Chain Across the Parkinson’s Disease Continuum
Objective: To evaluate plasma and PBMC biomarkers of neurodegeneration, neuroinflammation, microglial activation, and oxidative stress across clinically defined stages of Parkinson's disease (PD). Background: PD…Phenotypic Overlap Between Essential Tremor and Dystonic Tremor: Diagnostic Features, Misclassification, and Clinical Implications :A Systematic Review
Objective: To review evidence identifying clinical and neurophysiologic features that distinguish essential tremor from dystonic tremor and highlight patterns associated with diagnostic misclassification. Background: Distinguishing…Admixture Mapping of the VA Million Veteran Program Cohort Implicates Novel Genetic Risk Loci for PD Driven by African and Native American Ancestry
Objective: To perform an admixture mapping analysis for Parkinson’s disease (PD) in the Veterans Affairs (VA) Million Veteran Program (MVP) cohort. Background: The genetics of…Plasma Extracellular Vesicle Protein Biomarker Discovery for Monogenic and Sporadic Dystonia
Objective: To discover plasma biomarkers that differentiate people with dystonia from healthy controls (HC). Background: Blood-based biomarkers for dystonia could address several unmet clinical needs:…Reduced Motor Unit Discharge Variability of Wrist Muscles 24 Hours After Closed-Loop Electrical Stimulation in Essential Tremor
Objective: To investigate the acute and sustained effects of two peripheral electrical stimulation strategies on motor unit activity of wrist flexors and extensors in individuals…Biomechanical Analysis of Gait Movement Disorders in Spinal Cord Injury and Its Implications for Rehabilitation Strategies
Objective: To systematically analyze the spatiotemporal, kinematic, and electromyographic gait movement disorders in patients with partial SCI for targeted rehabilitation strategies. Background: Spinal cord injury…Pelizaeus Merzbacher like disease (PMLD): Neuroradiological Phenotyping
Objective: To present an unusual case report. Background: Pelizaeus Merzbacher like disease (PMLD) is a hypomyelination disorder, usually manifesting in neonatal or an early infantile…Post-COVID Movement Disorders: Clinical Spectrum and Mechanisms A Systematic Review
Objective: To synthesize published evidence describing the clinical spectrum and proposed mechanisms of movement disorders occurring after infection with SARS-CoV-2. Background: Neurological complications have been…Levels of IgA and IgG concentrations by stage of Parkinson’s disease
Objective: To study of IgA and IgG levels cerebrospinal fluid of patients with different stages of PD. Background: In the clinical course of Parkinson's disease…Efficacy and Safety of GLP-1 Receptor Agonists in Parkinson’s Disease: A Meta-Analysis Integrating the 96-Week Phase 3 Exenatide Trial Results
Objective: To evaluate the efficacy and safety of glucagon-like peptide-1 receptor agonists in patients with Parkinson’s disease (PD) through an updated systematic review and meta-analysis…
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