Comparative Study of limits of stability Improvements in Young-Onset vs. Late-Onset Parkinson’s Disease Following One-Year Biofeedback Balance Training
Objective: This study aims to assess the impact of balance training and early detection of stability limits in PD on the responsiveness of young and…Efficacy and Safety of IPX203 and Levodopa-Carbidopa Intestinal Gel (LCIG) Compared to Immediate-Release Carbidopa-Levodopa in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To conduct the efficacy and safety of IPX203, an extended-release carbidopa-levodopa formulation, and LCIG, a continuous levodopa infusion, compared to Immediate-Release Carbidopa-Levodopa (IR CD-LD)…Targeting inflammation and autophagy: a dual-inhibition strategy to reduce α-synuclein pathology in GBA1-associated Parkinson’s disease
Objective: To assess the effects of combined inhibition of mTOR (autophagy regulator) and STING (inflammation regulator) on α-synuclein phosphorylation, tyrosine hydroxylase expression, and lysosphingolipid levels in…A Phase 1b Study to Investigate Safety and Tolerability of Repeated Subcutaneous Doses of HER-096 in Subjects with Parkinson’s Disease
Objective: To investigate safety and tolerability of repeated subcutaneous (s.c.) doses of HER-096 in subjects with Parkinson’s disease. Background: HER-096 is a retro-inverso isomerized peptide…Remote Deep Brain Stimulation Programming for Parkinson’s Disease: A Multicenter Randomized Non-Inferiority Trial
Objective: To evaluate the effectiveness and safety of remote vs. on-site DBS programming in Parkinson’s disease patients with STN-DBS. Background: Deep brain stimulation (DBS) is…Exploring minzasolmin effect on digital measures captured by the Verily Study Watch in a subset of the ORCHESTRA trial participants
Objective: To investigate the progression over time and the effect of minzasolmin on digital outcomes collected in ORCHESTRA (NCT04658186). Background: Minzasolmin is an oral small…The cerebellum encodes dynamic motor frequencies for volitional movements
Objective: Investigate how the cerebellum computes and regulates motor precision during daily movements Background: Motor coordination, ensuring movement precision and reliability, is governed by the…Longitudinal Remote Monitoring with Wearable Technology in Parkinson Disease: Initiation of A Dyskinesia Insight Network Observational Study
Objective: Evaluate the utility of wearable digital health technology for identifying and characterizing levodopa-induced dyskinesia in real-world settings. Background: Patients with Parkinson disease (PwP) frequently…Trends on recruitment and retention in Parkinson’s Disease modification trials
Objective: To identify the most common causes of participant’s screen failure (SF) and drop-out (DO) in Phase 2 and 3 Disease Modification Therapy (DMT) trials…Enhancing Sleep in Parkinson’s Disease: A Retrospective Study on Group CBT-I
Objective: Weill Cornell Sleep Center and our movement disorder team developed a treatment program for individuals with Parkinson’s Disease (PD) with sleep disturbances. The goal…
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