LRRK2 Pathway Inhibition By NEU-411, a Potent, Selective, CNS-Penetrant LRRK2 Inhibitor In Healthy Participants
Objective: The aim of this work was to evaluate LRRK2 pathway modulation by the potent, selective, CNS-penetrant LRRK2 inhibitor NEU-411 in healthy adults and elderly…Semantic Memory Deficit as a Potential Risk Factor of Dementia in Isolated Rapid Eye Movement Sleep Behavior Disorder
Objective: We aimed to evaluate semantic memory (SM) performance in isolated/idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) and identify the specific profile of…Assessment of the impact of the diabetic features hyperglycemia and insulin resistance on fibril induced synucleinopathy
Objective: Investigate the effects of diabetic features on the induction and severity of synucleinopathies such as Parkinson’s disease (PD). Background: Type 2 diabetes (T2D) is…Increased “Off” Time Is Associated With Poorer Clinical and Humanistic Outcomes in Patients With Advancing Parkinson’s Disease: Results From the PROSPECT Observational Study
Objective: To evaluate the association of increased “Off” time with clinical and humanistic outcomes in people with advanced Parkinson’s disease (PwP) inadequately managed by oral…Anterior Pallidal Stimulation for Severe Tourette Syndrome: Open Phase Outcomes
Objective: To present the open phase outcomes of a trial of anterior pallidal stimulation (antGPi DBS) on tic severity in patients with severe Tourette syndrome…Shaking, Not Stirred: An Atypical Case of Propriospinal Myoclonus
Objective: To describe a rare presentation of propriospinal myoclonus (PSM) restricted to upper cervical segments and discuss the diagnostic challenge posed by its overlap with…A Phase 2 Study of Risvodetinib in Untreated Parkinson’s Disease
Objective: Risvodetinib was evaluated in a randomized, double-blind, placebo controlled Phase 2 trial at three doses to determine the safety and tolerability in patients with…Artificial Intelligence for Understanding Parkinson Disease State and Patient Stratification Using CSF Proteomics
Objective: The objective of this research is to employ an Artificial Intelligence (AI) approaches to identify patient status and disease states in neurodegenerative diseases (NDDs),…Focal Lower Limb Myoclonus Heralding Adult Onset Fulminant SSPE
Objective: We report a case adult onset fulminant SSPE with focal lower limb myoclonus as the predominant presenting movement disorder. Background: Myoclonus remains a defining…Clinical case of cerebellar ataxia associated with temporal bone tumor
Objective: To describe a clinical case of tumor-induced cerebellar ataxia in an elderly patient. Background: Ataxia can result from various etiologies, including neurodegenerative diseases, stroke,…
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