Integrating Multidisciplinary, Family-Centered Care to Optimize Functional Outcomes in Children with Cerebral Palsy.
Objective: Optimal management of Cerebral Palsy requires coordinated, evidence-based interventions that address both motor and non-motor domains across the lifespan. Background: Randomized controlled trials (RCTs)…Association of Glymphatic Flow at Diffusion Tensor Image with Motor Symptoms and Striatal Dopamine Degeneration in Parkinson’s Disease
Objective: This study aimed to investigate the association between the diffusion tensor image (DTI) analysis along the perivascular space (ALPS) index, dopamine transporter (DAT) availability…Linear-Time RWKV Multimodal Fusion of Smartphone Audio and Wearable Signals for Mild Cognitive Impairment Screening
Objective: To evaluate linear-time RWKV-based multimodal fusion for classifying mild cognitive impairment (MCI) from synchronized smartphone audio and consumer wearable signals, and to compare alternative…Diagnosing Prodromal Synucleinopathies – What is the Role of Cardiac MIBG Scintigraphy?
Objective: We aimed to characterize cardiac MIBG uptake patterns in patients with an initial diagnosis of PAF (iPAF) and assess their role as a prognostic…Modulation of Excitatory/Inhibitory Neurotransmission via Targeting GABAA-Gephyrin Signaling: Integrated In-Silico, In-Vitro, and In-Vivo Evidence in Parkinson’s Disease Models
Objective: To evaluate the neuroprotective potential of wogonin in modulating excitatory–inhibitory neurotransmission via GABAA receptor and gephyrin signaling in rat models of Parkinson’s disease (PD).…Sex Differences for Primary Psychiatric Diagnoses and Associated Care Outcomes in Dementia with Lewy Bodies using Epic Cosmos
Objective: Assess sex differences for documented primary psychiatric diagnoses in people with dementia with Lewy bodies (DLB) and their associations with care outcomes (hospitalization, specialty…Bridging the Genomic Gap: Ancestry-Aware Polygenic Risk and Variant Discovery in African Parkinson’s Disease Cohorts
Objective: This study evaluates the shift from Euro-centric data to a diversified landscape. We aim to quantify the performance of European-derived Polygenic Risk Scores (PRS)…Intrafamilial Phenotypic Diversity Associated with Coexisting LRRK2 G2385R and a Novel GCH1 Variant: A Case Report
Objective: To describe intrafamilial phenotypic variability associated with the coexisting LRRK2 G2385R and a novel GCH1 variant in a family presenting with parkinsonism and dystonia…THD (Tyrosine Hydroxylase Deficiency) in a 39-Year-Old Woman with Early-Onset Dystonia
Objective: To report a case of tyrosine hydroxylase deficiency (THD), a rare neurometabolic disorder that disrupts catecholamine biosynthesis. This case report highlights common neurologic abnormalities,…Predicting Parkinson’s: Navigating Risk, Rights, and Regulation
Objective: This study explores the legal and ethical challenges surrounding predictive testing for Parkinson’s disease (PD), with a particular focus on its impact in employment,…
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