Diagnosing Prodromal Synucleinopathies – What is the Role of Cardiac MIBG Scintigraphy?
Objective: We aimed to characterize cardiac MIBG uptake patterns in patients with an initial diagnosis of PAF (iPAF) and assess their role as a prognostic…Modulation of Excitatory/Inhibitory Neurotransmission via Targeting GABAA-Gephyrin Signaling: Integrated In-Silico, In-Vitro, and In-Vivo Evidence in Parkinson’s Disease Models
Objective: To evaluate the neuroprotective potential of wogonin in modulating excitatory–inhibitory neurotransmission via GABAA receptor and gephyrin signaling in rat models of Parkinson’s disease (PD).…Sex Differences for Primary Psychiatric Diagnoses and Associated Care Outcomes in Dementia with Lewy Bodies using Epic Cosmos
Objective: Assess sex differences for documented primary psychiatric diagnoses in people with dementia with Lewy bodies (DLB) and their associations with care outcomes (hospitalization, specialty…Bridging the Genomic Gap: Ancestry-Aware Polygenic Risk and Variant Discovery in African Parkinson’s Disease Cohorts
Objective: This study evaluates the shift from Euro-centric data to a diversified landscape. We aim to quantify the performance of European-derived Polygenic Risk Scores (PRS)…Intrafamilial Phenotypic Diversity Associated with Coexisting LRRK2 G2385R and a Novel GCH1 Variant: A Case Report
Objective: To describe intrafamilial phenotypic variability associated with the coexisting LRRK2 G2385R and a novel GCH1 variant in a family presenting with parkinsonism and dystonia…THD (Tyrosine Hydroxylase Deficiency) in a 39-Year-Old Woman with Early-Onset Dystonia
Objective: To report a case of tyrosine hydroxylase deficiency (THD), a rare neurometabolic disorder that disrupts catecholamine biosynthesis. This case report highlights common neurologic abnormalities,…Predicting Parkinson’s: Navigating Risk, Rights, and Regulation
Objective: This study explores the legal and ethical challenges surrounding predictive testing for Parkinson’s disease (PD), with a particular focus on its impact in employment,…Risk factors associated with Parkinson’s disease in the DRC (Case of the Initiative Plus Hospital Center, Kinshasa)
Objective: identify factors that could be associated with Parkinson's disease in Congo Background: In DRCongo, few studies have been published on Parkinson's disease to date.At…Digital Health, Telemedicine, and Artificial Intelligence in Parkinson’s Disease Management During COVID-19: A Narrative Review
Objective: The objective of this narrative review was to evaluate the effectiveness of telemedicine and AI-based technologies used for the remote monitoring and management of…Intestinal Dysbiosis in Parkinson’s Disease: Mechanisms, Clinical Implications, and Therapeutic Perspectives (2015–2025)
Objective: This narrative review aims to consolidate research published from 2015 to 2025 regarding abnormalities in gut microbiota in patients with Parkinson’s disease, emphasizing potential…
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