AI based longitudinal changes in substantia nigra contrast and volume on neuromelanin MRI and its relation to clinical markers in a multi-site Parkinson’s disease study.
Objective: To apply an AI model in a multi-site longitudinal study to segment substantia nigra pars compacta (SNpc), perform longitudinal analysis, and quantify its association…Dopaminergic denervation and focal motor progression in early Parkinson’s Disease: A 5-year longitudinal study
Objective: To evaluate the progression of posterior putamen dopaminergic denervation in relation to motor progression in the less affected and more affected side of the…Regional Brain Volume Differences Across PD Clinical Subtypes
Objective: To investigate brain morphometric differences across Parkinson disease (PD) clinical subtypes. Background: We developed a PD subtype classification with three subtypes that includes motor…Reduced parietal and sensorimotor cortex recruitment during complex gait in Parkinson’s disease patients with freezing of gait
Objective: To investigate cortical brain activity changes during complex gait in Parkinson’s disease (PD) patients with and without freezing of gait (FOG) using functional near…Characterization of a Novel alpha-synuclein PET radiotracer, [18F]C05-05, in a PPMI Sub-study
Objective: Characterization of the PET radiotracer, [18F]C05-05, in the PPMI Study Background: Validation of imaging biomarkers in Parkinson disease (PD) is a major objective of…MRI Visible Perivascular Spaces are Associated with Disease Duration and Severity in Parkinson’s Disease
Objective: Determine whether enlarged perivascular spaces (ePVS) in Parkinson's disease (PD) is associated with worsening motor symptoms and disease progression. Background: PVS are fluid-filled channels…Characterizing levodopa-induced dyskinesias using multimodal neuroimaging, clinical and behavioral measures
Objective: Our objective is to investigate potential differential modulation in motor and executive function networks among patients with LID, and to explore its correlation with…Refining and Understanding Causal Relationships between Brain Imaging-Derived Phenotypes and Parkinson’s Disease: a Bidirectional Mendelian Randomization Study and Clinical Validation
Objective: Utilizing bidirectional two-sample Mendelian randomization, we explored the causal associations between imaging-derived phenotypes (IDPs) and Parkinson's Disease (PD), along with its manifestations. Background: Observational…Mapping Cholinergic Signaling in Parkinson Disease Using [18F]VAT
Objective: To determine how cholinergic signaling changes within Parkinson Disease (PD) and how these differences relate to the progression of cognitive and behavioral symptoms. Background:…Naturalistic walking in Parkinson’s disease: Prefrontal cortex activity measured with functional near-infrared spectroscopy (fNIRS)
Objective: In persons with Parkinson’s disease (PwPD), to observe brain activity in prefrontal cortex (PFC) using fNIRS during naturalistic walking that mimics everyday scenarios1, with…
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