MRI biomarkers of freezing of gait development in in Parkinson’s disease
Objective: This study investigated longitudinal clinical, structural and functional brain alterations in Parkinson’s disease patients with freezing of gait (PD-FoG) and in those developing (PD-FoG-converters)…Motor-Related and Cognition-Related Safety of Pimavanserin in Patients with Parkinson’s Disease Psychosis (PDP)
Objective: Evaluate motor- and cognition-related safety in pimavanserin-treated patients with PDP. Background: Pimavanserin, a selective 5-HT2A inverse agonist/antagonist, is the only US FDA-approved treatment for…Paliperidone induced neuroleptic malignant syndrome treated with electroconvulsive therapy and continuous apomorphine: A case report
Objective: Neuroleptic malignant syndrome (NMS) is a neurological emergency that is often induced by antipsychotic drugs. NMS may be mortal if left untreated. Background: In…BIOMARKERS OF PARKINSONISM AND POSSIBILITIES OF PREDICTION OF THE COURSE OF PARKINSON’S DISEASE
Objective: Parkinsonism is one of the most significant problems in clinical neurology, both due to its high prevalence in the world's populations and due to…Continuous subcutaneous apomorphine infusion for the management of Parkinson’s disease at the end-of-life
Objective: To describe the benefit of continuous subcutaneous apomorphine infusion (CSAI) for terminal care management in 7 PD patients. Background: There are currently no recommendations…Adrenergic blockers and statins are associated with later age of onset in Parkinson’s disease
Objective: To evaluate the association of anti-hypertensives, non-steroidal anti-inflammatories (NSAIDs), statins, diabetes medications, smoking and family history of idiopathic Parkinson’s disease (iPD) with age of…Analysis of somatosensory temporal discrimination in essential tremor treated with HIFU VIM thalamotomy: tremoric and lesional effects on the STDT
Objective: To compare somatosensory temporal discrimination threshold (STDT) previously and 4 months after unilateral (left) high intensity focused ultrasound (HIFU) thalamotomy. Secondly, to observe the…Phase-amplitude coupling between beta power and high frequency oscillations as a sensitive marker of parkinsonian state.
Objective: The aim of this work was to study the potential clinical usefulness of the phase-amplitude coupling (PAC) between beta power and high frequency oscillations (HFO´s).…Evolution of biochemical and clinical signature of GBA-related Parkinson’s Disease: a 2-year longitudinal study
Objective: To evaluate peripheral biochemical markers as well as clinical features of GBA-related Parkinson’s Disease (GBA-PD) subjects over a 2-year follow-up in comparison with NM-PD…Systematic Literature Review of Key Outcomes Used to Assess Adjunctive Treatments for Parkinson’s Disease
Objective: Understand key efficacy outcomes used to assess adjunctive treatments to carbidopa/levodopa (CD/LD) for Parkinson’s disease (PD). Background: CD/LD is widely considered the most effective…
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