Lysosomal storage disorder genes variants in Parkinson’s disease: a large cohort study in Chinese mainland population
Objective: In this study, we investigated the association between rare variants in lysosomal storage disorders (LSDs) genes and Parkinson’s disease in large Chinese mainland cohorts.…Antioxidants in foods: A Primary Potential remedy to Neurodegeneration.
Objective: The aim of the research is to establish the plausibility of reducing the effects of the actions of reactive oxygen species, produced by glutamate…Integrated Multi-omics of the Gut Microbiome Reveal 2-Hydroxypyridine as a Novel Molecule Relevant to Parkinson’s Disease Pathogenesis
Objective: To search for molecular links between Parkinson’s disease (PD) pathogenesis and gut microbes based on integrated multi-omic analyses of fecal samples from patients with…Targeted plasmaproteome identifies a distinct biomarker panel in early and prodromal Parkinson’s disease
Objective: To identify protein biomarkers in plasma of patients with Parkinson’s disease (PD). Background: Inflammation plays a key role in the initiation and progression of…The role of amylin in Parkinson´s disease neurodegenerative process
Objective: We investigate the functional interaction between two amyloidogenic (amylin and synuclein) proteins as a potential mechanism for neurodegeneration in Parkinson disease (PD). Background: PD…Rapamycin attenuates nigral and hippocampal alpha-synuclein accumulation in AAV-mediated alpha-synuclein overexpression model of Parkinson’s disease
Objective: To examine the possible neurorestorative effects of chronic rapamycin treatment in AAV-mediated alpha-synuclein (a-syn) overexpression model of Parkinson’s disease (PD), designed to induce hippocampal…Fatty acids and Glucocerebrosidase activity as potential biomarkers of stearyl-CoA desaturase inhibition; an observational study of inter and intraday variation in healthy volunteers and patients with Parkinson’s disease
Objective: This study aimed to assess the naturally occurring levels and variation in plasma fatty acids (FA) and ceramide metabolism in healthy volunteers (HV) and…CHARACTERIZATION OF LRP10 EXPRESSION IN LEWY BODY DISORDERS AND IPSC-DERIVED BRAIN CELLS
Objective: Our objective is to characterize endogenous low-density lipoprotein-related protein 10 (LRP10) expression in human induced pluripotent stem cell (iPSC)-derived brain cell types, post-mortem brain…Effects of fine particulate matter and cigarette smoking on MPTP-induced dopaminergic neuronal cell death: Implication for Parkinson’s disease
Objective: The objective of this study was to determine the potential neurotoxicity of fine particulate matter (FPM) and the neuroprotective properties of nicotine in the pathogenesis…Next-generation sequencing of plasma-associated extracellular vesicle miRNAs as potential biomarkers for Parkinson’s disease and its prodromal stage
Objective: This study aimed to identify subsets of plasma EV-associated miRNAs with diagnostic potential for PD and iRBD, the prodromal stage of PD. Background: Parkinson’s…
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