Gut dysbiosis in Parkinson’s disease with motor complications
Objective: We aimed to identify gut dysbiosis in Parkinson's disease patients with motor complications. Background: Recently, several evidences suggest that the gut microbiota is associated…Mutations in GBA and LRRK2 are not associated with increased inflammatory markers
Objective: To assess central and peripheral cytokines among Parkinson's disease (PD) patients with mutations in the LRRK2 and GBA genes as well as among non-manifesting…Parkinson’s Families Project: analysis of a large cohort of patients with early onset and familial Parkinson’s disease
Objective: We aim to identify new gene variants associated with familial and early-onset Parkinson's disease (PD), through genetic comparison of affected and unaffected family members.…LIPAD (LRRK2/Luebeck) International Parkinson’s Disease Study: Protocol and feasibility study
Objective: To systematically assess clinical signs and symptoms including non-motor features, comorbidities, medication and environmental factors in 1,000 participants internationally: 300 with LRRK2 (Leucine-rich repeat…Axial Impairment Following Deep Brain Stimulation in Parkinson’s Disease: a Surgicogenomic Approach
Objective: We aimed to identify genetic variants associated with clinical heterogeneity in deep brain stimulation outcome of Parkinson’s Disease patients with an overall objective of…Comprehensive analysis of PRKN in a large Parkinson’s Disease cohort identifies causative mutations and validates population scale screening by microarray
Objective: To screen for PRKN mutations at the population scale. Background: PRKN mutations are the most common recessive cause of Parkinson’s disease (PD) and are…Silencing of hypoxia-inducible factor 1 alpha provokes a neuroprotective response in a SH-SY5Y model of Parkinson’s Disease.
Objective: Our study aims to delineate the role of HIF1α in a SH-SY5Y model of Parkinson’s disease (PD) Background: Parkinson’s disease (PD) is one of…Integrated Multi-omics of the Gut Microbiome Reveal 2-Hydroxypyridine as a Novel Molecule Relevant to Parkinson’s Disease Pathogenesis
Objective: To search for molecular links between Parkinson’s disease (PD) pathogenesis and gut microbes based on integrated multi-omic analyses of fecal samples from patients with…MicroRNAs as a potential biomarker of Parkinson’s disease
Objective: Our study was aimed at analyzing the role of microRNA as a potential biomarker of PD. Background: A substantial part of cases of Parkinson’s…Parkinson’s disease-linked LDL Receptor Related Protein 10 (LRP10) is implicated in regulation of the secretory and autophagy-lysosome pathways
Objective: We aim to investigate the potential roles of LRP10 defects in PD, PDD and DLB, focusing on two pathways known to be central in…
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