Blood-based circulating microRNAs for discriminating between Parkinson’s disease subtypes
Objective: The aim of this study was to establish candidate blood miRNAs biomarkers for PD by comparing differences in miRNAs expression between distinct PD subtypes. Background: Blood…Serial DaT-SPECT imaging in asymptomatic carriers of LRRK2 G2019S mutation: 8-years follow-up
Objective: To characterize the 8-year progression of clinical and imaging biomarkers in a cohort of asymptomatic LRRK2 G2019S carriers and to assess its utility as predictors of…Parkinsonism in individuals with genetic neurodevelopmental disorders: A systematic review
Objective: It is increasingly recognized that individuals with genetic neurodevelopmental disorders (GNDs) such as 22q11.2 deletion syndrome can suffer from parkinsonism. We aim to provide…Lack of diversity in Parkinson’s disease genetic research: current landscape and future directions
Objective: We conducted a systematic review to summarize past studies on Parkinson's disease (PD) genetics research among underrepresented populations (URP), defined as being non-European ancestry. We…Stratified genome-wide association study revealed novel interactions for the top hit Parkinson’s disease loci.
Objective: To identify genetic modifiers and interactors that may modulate known risk variants in the SNCA, TMEM175 and MAPT loci in Parkinson’s disease (PD). Background:…Reduced serum PRDX3 levels are a biomarker for Asian LRRK2 carriers in Parkinson’s disease
Objective: We measured serum peroxiredoxin-3 (PRDX3) levels in Parkinson’s disease (PD) patients with and without LRRK2 risk variants, hypothesizing that PD LRRK2 carriers will show…Homozygous PRKN exon 3 deletion in an early-onset Parkinson’s disease family from the Kadazan-Dusun ethnic group indigenous to Sabah, Malaysia
Objective: To determine the causal gene for early-onset Parkinson’s disease (PD) in a Malaysian family of Kadazan-Dusun ethnicity. Background: Among Asian populations, relatively little is…Parkinson’s Families Project: analysis of a large cohort of patients with early onset and familial Parkinson’s disease
Objective: We aim to identify new gene variants associated with familial and early-onset Parkinson's disease (PD), through genetic comparison of affected and unaffected family members.…Genotype-phenotype relations for GBA as a Parkinson’s disease risk factor gene: MDSGene Systematic Review
Objective: To provide a comprehensive and systematic review of genotype-phenotype associations of GBA variants for Parkinson’s disease (PD). Background: Biallelic pathogenic variants in the glucocerebrosidase gene (GBA) cause Gaucher disease (GD).…The MJFF Global Genetic Parkinson’s Disease Research Resource
Objective: To establish a comprehensive research and clinical trial-ready resource of centers working with individuals with monogenic Parkinson’s Disease (PD). Background: As gene-targeted therapies are…
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