Lack of Toll-like receptor 4 is associated with accumulation of alpha-synuclein in the midbrain Parkinson’s disease mice.
Objective: In this study we aimed to investigate the potential role of Toll-like receptor 4 (TLR4) in mediating both the dopaminergic neuron loss and alpha-synuclein (alpha-SYN)…Co-contractions as a Biomarker for DBS Efficacy in Dystonia
Objective: Deep brain stimulation of the globus pallidus interna (GPi-DBS) is a treatment option for medication-refractory dystonia. However, the clinical outcome after DBS-GPi is variable,…Remote identification of early, sensor-based markers of Parkinson’s Disease using participants’ smartphones: The Parkinson Progression Marker Initiative Digital sub-study
Objective: To summarize the design of the Parkinson’s Progression Markers Initiative (PPMI) Digital sub-study. The study objective is to identify the earliest signs and symptoms…Non-myoclonic Subacute Sclerosing Pan Encephalitis in Adulthood
Objective: We report a case of subacute sclerosing panencephalitis (SSPE) presenting after a long latency without the usual clinical clues that aid in diagnosis. Background:…A systematic review of non-motor symptoms in atypical parkinsonian syndromes
Objective: We wanted to systematically analyse the repertoire of NMS in patients with progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD) and…Gait Characteristics from Daily Life Increase Ability to Predict Future Falls in People with Parkinson’s Disease
Objective: We investigated if digital measures of different aspects of gait (walking and turning) from a week of daily activities increase discriminative ability to predict…Profiling the biochemical lysosomal activities in blood of patients with LRRK2 G2019S associated Parkinson’s disease
Objective: To replicate the previous study of Alcalay and coauthors on estimation of lysosomal enzymes activities [1] with additional estimation of corresponding substrates in patients…A patient with childhood-onset hearing loss and adult-onset ataxia was genetically diagnosed with Perrault syndrome 5
Objective: A case of adult-onset ataxia with multiple neurologic deficits and ovarian dysgenesis was genetically diagnosed as Perrault syndrome 5 for the first time in…COMPARISON OF CERVICAL, OCULAR AND MASSETER VESTIBULAR EVOKED MYOGENIC POTENTIALS IN PARKINSON PATIENTS ACCORDING TO CLINICAL SUBGROUPS
Objective: The aim of this study is to reveal the differences in the effect of brainstem reflexes between the motor subtypes of PD, akinetic rigid(AR)…SCFAs participate in the pathogenesis of Parkinson’s disease by regulating NLRP3 inflammasomes activation
Objective: To explore the role and related mechanism of gut microbiota metabolites short-chain fatty acids(SCFAs) in the pathogenesis of Parkinson's disease(PD). Background: Growing research have…
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