Session Information
Date: Monday, September 23, 2019
Session Title: Psychiatric Manifestations
Session Time: 1:45pm-3:15pm
Location: Les Muses Terrace, Level 3
Objective: Objective of the study was to analyze the risk factors for the development of these behaviors.
Background: Impulsive compulsive behaviors (ICBs) are a frequent complication in Parkinson’s disease (PD), occurring in up to 20% of PD patients [1]. These disorders have a significant impact on quality of life, straining relationships, and worsening caregiver burden.
Method: 251 PD patients receiving outpatient care at our Centre were consecutively enrolled. After clinical data were collected, each patient underwent a quick interview to determine whether or not they were suitable for ICBs diagnosis. Then QUIP, BIS, MoCA, AES and Olfactory Identification Test (IOIT) were administered to all the patients. Reliability of the Italian version of the Questionnaire for Impulsive and Compulsive Behaviors (QUIP) was also tested.
Results: The prevalence of ICBs was 31.1%. Age of disease onset (p < 0.001), longer PD duration (p< 0.001) and Hoehn & Yahr stage (p=0.020) were related to QUIP positivity. No significant correlation with non-motor symptoms were found, including apathy (AES), cognitive deficits (MoCA) or olfactory dysfunction. Regarding dopamine replacement therapy, total daily dosage of levodopa (p = 0.017), dopamine agonists (OR=1.8 95%CI=1.0-3.2) as well as entacapone use (OR=2.8 95% CI=1.1-7. 4) were associated with higher risk of developing ICBs. I-QUIP test-retest reliability was demonstrated.
Conclusion: Dopamine replacement therapy is associated with increased odds of having ICBs. Other significant risk factors included younger age, longer disease duration and a more severe disease presentation. No correlation with the non-motor features analyzed was found.
References: [1] Weintraub D, Koester J, Potenza MN, et al. Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients. Arch. Neurol. 2010;67(5):589-595.
To cite this abstract in AMA style:
S. Simoni, N. Tambasco, P. Eusebi, P. Nigro, E. Brahimi, F. Paolini Paoletti, M. Filidei, G. Cappelletti, P. Calabresi. Prevalence and risk factors for impulsive compulsive behaviors in a cohort of Parkinson’s disease patients [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/prevalence-and-risk-factors-for-impulsive-compulsive-behaviors-in-a-cohort-of-parkinsons-disease-patients/. Accessed June 14, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/prevalence-and-risk-factors-for-impulsive-compulsive-behaviors-in-a-cohort-of-parkinsons-disease-patients/