Objective: Conduct a descriptive analysis of the Colombian Parkinson’s disease population and its comorbidities using data from the Colombian Ministry of Health.Estimate the prevalence and geographical distribution of Parkinson’s disease in Colombia.Estimate the prevalence ratio of obstructive sleep apnea, urinary incontinence, dementia, and depression in individuals with Parkinson’s disease to assess their impact on healthcare needs in urban and rural areas
Background: Parkinson disease is a highly prevalent neurodegenerative disorder with social and economic implications, which make it important to estimate its prevalence and to describe the main demographic features of patients with PD and their comorbidities, in middle income countries such as Colombia based on data collected from the Ministry of Health, SISPRO (a national health registry gathering information from the National Health System) which covers approximately 95% of the Colombian Population
Method: We accessed SISPRO and collected data regarding patients with PD from 2018 through 2022, which were analyzed based on sex, age and geographic location. In addition to data regarding PD, we collected information about obstructive sleep apnea, urinary incontinence, dementia and depression, with which we calculated prevalence ratios for each disease
Results: The raw disease prevalence was 5.42 per 1000 people older than 50 years old (6.65 in men and 4.42 in women); and 9.87 per 1000 people older than 65 years old (12.01 in men and 8.15 in women) in Colombia. Although most of the diagnosis kept taking place in the big cities, some smaller cities have increased their rate of diagnosis, suggesting a decrease in underdiagnosis seen in previous years. Prevalence ratios in people older than 50 years were 3.7 and 4.3 for depression and mild depression, respectively, 2.9 for urinary incontinence, 2.4 for obstructive sleep apnea, and 14.3 for dementia
Conclusion: This study features the prevalence of PD and its related comorbidities, highlighting the need for a multidisciplinary approach when managing this complex disease.
An abstract with similar methodology was presented in the 2022 International Congress. However it focused on atypical Parkinsonisms and in a different time frame.
Title: Prevalence of Parkinson’s disease and Atypical Parkinsonisms in Colombia: Data from the national health registry 2016-2021
Age distribution of patients diagnosed with PD
Prevalence of PD by department
Table 1. PD age distribution
References: 1. Bloem BR, Okun MS, Klein C. Parkinson’s disease. Lancet. 2021;397(10291):2284-303.
https://doi.org/10.1016/S0140-6736(21)00218-X
2. Sveinbjornsdottir S. The clinical symptoms of Parkinson’s disease. J Neurochem. 2016;139(S1):318-24.
https://doi.org/10.1111/jnc.13691
3. Prakash KM, Nadkarni NV, Lye W‐K., Yong M‐H., Tan E‐K. The impact of non‐motor symptoms on the quality of life of Parkinson’s disease patients: a longitudinal study. Eur J Neurol. 2016;23(5):854-60.
https://doi.org/10.1111/ene.12950
4. Dorsey ER, Sherer T, Okun MS, Bloem BR. The emerging evidence of the Parkinson pandemic. Brundin P, Langston JW, Bloem BR, editors. J Park Dis. 2018;8(s1):S3-8.
https://doi.org/10.3233/JPD-181474
5. Hirsch L, Jette N, Frolkis A, Steeves T, Pringsheim T. The incidence of Parkinson’s disease: A systematic review and meta-analysis. Neuroepidemiology. 2016;46(4):292-300.
https://doi.org/10.1159/000445751
6. Gonzalez-Alvarez MA, Hernandez-Bonilla D, Plascencia-Alvarez NI, Riojas-Rodriguez H, Rosselli D. Environmental and occupational exposure to metals (manganese, mercury, iron) and Parkinson’s disease in low and middle-income countries: a narrative review. Rev Environ Health. 2022;37(1):1-11.
https://doi.org/10.1515/reveh-2020-0140
7. Marras C, Beck JC, Bower JH, Roberts E, Ritz B, Ross GW, et al. Prevalence of Parkinson’s disease across North America. Npj Park Dis. 2018;4(1):21.
https://doi.org/10.1038/s41531-018-0058-0
8. Zhong QQ, Zhu F. Trends in prevalence cases and disability-adjusted life-years of Parkinson’s disease: findings from the global burden of disease study 2019. Neuroepidemiology. 2022;56(4):261-70.
https://doi.org/10.1159/000524208
9. Armstrong MJ, Okun MS. Time for a new image of Parkinson disease. JAMA Neurol. 2020;77(11):1345.
https://doi.org/10.1001/jamaneurol.2020.2412
10. Wright Willis A, Evanoff BA, Lian M, Criswell SR, Racette BA. geographic and ethnic variation in Parkinson disease: A population-based study of US Medicare beneficiaries. Neuroepidemiology. 2010;34(3):143-51.
https://doi.org/10.1159/000275491
11. Moisan F, Kab S, Mohamed F, Canonico M, Le Guern M, Quintin C, et al. Parkinson disease male-to-female ratios increase with age: French nationwide study and meta-analysis. J Neurol Neurosurg Psychiatry. 2016;87(9):952-7.
https://doi.org/10.1136/jnnp-2015-312283
12. Han S, Kim S, Kim H, Shin HW, Na KS, Suh HS. Prevalence and incidence of Parkinson’s disease and drug-induced parkinsonism in Korea. BMC Public Health. 2019 Dec;19(1):1328.
https://doi.org/10.1186/s12889-019-7664-6
13. Jacobs E, D’Esposito M. Estrogen Shapes Dopamine-Dependent Cognitive Processes: Implications for Women’s Health. J Neurosci. 2011;31(14):5286-93.
https://doi.org/10.1523/JNEUROSCI.6394-10.2011
14. Ishihara L, Brayne C. A systematic review of depression and mental illness preceding Parkinson’s disease. Acta Neurol Scand. 2006;113(4):211-20.
https://doi.org/10.1111/j.1600-0404.2006.00579.x
15. Marsh L. Depression and Parkinson’s disease: current knowledge. Curr Neurol Neurosci Rep. 2013;13(12):409.
https://doi.org/10.1007/s11910-013-0409-5
16. Aarsland D, Påhlhagen S, Ballard CG, Ehrt U, Svenningsson P. Depression in Parkinson disease-epidemiology, mechanisms and management. Nat Rev Neurol. 2012;8(1):35-47.
https://doi.org/10.1038/nrneurol.2011.189
17. Chen J, Tsai T, Li C, Hwang J. Obstructive sleep apnea and risk of Parkinson’s disease: a population‐based cohort study. J Sleep Res. 2015;24(4):432-7.
https://doi.org/10.1111/jsr.12289
18. Lajoie AC, Lafontaine AL, Kimoff RJ, Kaminska M. Obstructive sleep apnea in neurodegenerative disorders: Current evidence in support of benefit from sleep apnea treatment. J Clin Med. 2020;9(2):297.
https://doi.org/10.3390/jcm9020297
19. Kaminska M, Lafontaine AL, Kimoff RJ. The interaction between obstructive sleep spnea and Parkinson’s disease: Possible mechanisms and implications for cognitive function. Park Dis. 2015;2015:1-11.
https://doi.org/10.1155/2015/849472
20. Trotti LM, Bliwise DL. No increased risk of obstructive sleep apnea in Parkinson’s disease. Mov Disord. 2010;25(13):2246-9.
https://doi.org/10.1002/mds.23231
21. Oh Y, Kim J, Lyoo CH, Kim H. Obstructive sleep apnea and striatal dopamine availability in Parkinson’s disease. Mov Disord. 2023;38(6):1068-76.
https://doi.org/10.1002/mds.29402
22. Ramos C, Aguillon D, Cordano C, Lopera F. Genetics of dementia: insights from Latin America. Dement Neuropsychol. 2020;14(3):223-36.
https://doi.org/10.1590/1980-57642020dn14-030004
23. Pradilla A. G, Vesga A. BE, León-Sarmiento FE. Estudio neuroepidemiológico nacional (EPINEURO) colombiano. Rev Panam Salud Pública. 2003;14(2):104-11.
https://doi.org/10.1590/S1020-49892003000700005
24. Rosselli D, Pantoja-Ruiz C. SISPRO: La base de datos administrativa del sistema de salud colombiano. Acta Neurol Colomb. 2022;38(4)187-90.
https://doi.org/10.22379/24224022426
25. Jiménez-Pérez CE, Zarco-Montero LA, Castañeda-Cardona C, Otálora Esteban M, Martínez A, Rosselli D. Estado actual de la esclerosis múltiple en Colombia. Acta Neurol Colomb. 2015;31(4):385-90.
https://doi.org/10.22379/2422402256
26. Méndez-Ayala A, Nariño D, Rosselli D. Burden of epilepsy in Colombia. Neuroepidemiology. 2015;44(3):144-8.
https://doi.org/10.1159/000381424
27. Kim DJ, Isidro‐Pérez AL, Doering M, Llibre‐Rodriguez JJ, Acosta I, Rodriguez Salgado AM, et al. Prevalence and incidence of Parkinson’s disease in Latin America: A meta‐analysis. Mov Disord. 2024;39(1):105-18.
https://doi.org/10.1002/mds.29682
28. Ou Z, Pan J, Tang S, Duan D, Yu D, Nong H, et al. Global trends in the incidence, prevalence, and years lived with disability of Parkinson’s disease in 204 countries/territories from 1990 to 2019. Front Public Health. 2021;9:776847.
https://doi.org/10.3389/fpubh.2021.776847
29. Sun AP, Liu N, Zhang YS, Zhao HY, Liu XL. The relationship between obstructive sleep apnea and Parkinson’s disease: a systematic review and meta-analysis. Neurol Sci. 2020;41(5):1153-62.
https://doi.org/10.1007/s10072-019-04211-9
30. Mery VP, Gros P, Lafontaine AL, Robinson A, Benedetti A, Kimoff RJ, et al. Reduced cognitive function in patients with Parkinson disease and obstructive sleep apnea. Neurology. 2017;88(12):1120-8.
https://doi.org/10.1212/WNL.0000000000003738
31. Bottia S, Barrios-Bermúdez H, Rosselli D. Prevalencia de apnea de sueño en Colombia: un análisis de las bases de datos del Ministerio de Salud. Iatreia 2024;37(1)26-34.
https://doi.org/10.17533/udea.iatreia.222
32. Ortiz JL, Rosselli D. Adherence to positive airway pressure therapy in a cohort of Colombian patients with obstructive sleep apnea syndrome. Sleep Sci. 2023;16(02):227-30.
https://doi.org/10.1055/s-0043-1770799
33. Crosta F. Obstructive sleep apnea syndrome in Parkinson’s disease and other parkinsonisms. Funct Neurol. 2017;37(3):137.
https://doi.org/10.11138/FNeur/2017.32.3.137
34. Belarbi S, Hecham N, Lesage S, Kediha MI, Smail N, Benhassine T, et al. LRRK2 G2019S mutation in Parkinson’s disease: A neuropsychological and neuropsychiatric study in a large Algerian cohort. Parkinsonism Relat Disord. 2010;16(10):676-9.
https://doi.org/10.1016/j.parkreldis.2010.09.003
35. Li FF, Cui YS, Yan R, Cao SS, Feng T. Prevalence of lower urinary tract symptoms, urinary incontinence and retention in Parkinson’s disease: A systematic review and meta-analysis. Front Aging Neurosci. 2022;14:977572.
https://doi.org/10.3389/fnagi.2022.977572
36. Yeo L, Singh R, Gundeti M, Barua JM, Masood J. Urinary tract dysfunction in Parkinson’s disease: a review. Int Urol Nephrol. 2012;44(2):415-24.
https://doi.org/10.1007/s11255-011-9969-y
To cite this abstract in AMA style:
A. Rincon, C. Pantoja, J. Torres, C. Tamayo, D. Rosselli. Prevalence, demographic characteristics of Parkinson disease and associated comorbidities: An analysis of the Colombian Ministry of Health official registry [abstract]. Mov Disord. 2025; 40 (suppl 1). https://www.mdsabstracts.org/abstract/prevalence-demographic-characteristics-of-parkinson-disease-and-associated-comorbidities-an-analysis-of-the-colombian-ministry-of-health-official-registry/. Accessed October 5, 2025.« Back to 2025 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/prevalence-demographic-characteristics-of-parkinson-disease-and-associated-comorbidities-an-analysis-of-the-colombian-ministry-of-health-official-registry/