Objective: 1. To evaluate the quality of life (QoL) profile of Parkinson’s disease (PD) patients in a multidisciplinary clinic in a tertiary hospital in Hong Kong. 2. To evaluate the major determinants of QoL of these patients.

Background: PD is a neurodegenerative disease with both motor and non-motor symptoms. It can affect the daily functioning and QoL of both the patients and their caregivers. However, few studies concerning QoL have been conducted, especially in the Asian population.

Methods: We conduct a cross-sectional study in the multidisciplinary PD clinic in a tertiary hospital in Hong Kong. All Asian PD patients, who were followed in the multidisciplinary clinic, were recruited. Their demographic information were documented. Their motor function was evaluated with Hoehn and Yahn (H&Y) stage and Unified Parkinson’s disease Rating Scale motor score (UPDRS III) while the non-motor function was assessed with Non Motor Symptoms Scale (NMSS). Their quality of life was assessed by the 39-item Parkinson’s disease Questionnaire (PDQ-39). The correlation between different clinical factors and PDQ-3i was evaluated with Spearman’s rank correlation coefficient.

Results: 145 PD patients were recruited between 2014 and 2015. Their mean age was 64.87 ± 9.44. Their mean disease duration was 7.97 ± 5.36 years. The mean PDQ-39 total score of our cohort was 35.96 ± 23.42 while that of PDQ-39 summary index was 20.86 ± 13.28. Among the eight PDQ-39 domains, mobility had the highest dimension score, followed by cognitions and bodily discomfort. Both motor (rs of H&Y stage: 0.420; rs of UPDRS III: 0.349) and non-motor symptoms (rs of NMSS: 0.603) was found to be correlated with PDQ-39 summary index. However, it was reported that non-motor symptoms, especially mood (rs of mood: 0.521) and sleep dysfunction (rs of sleep disorder: 0.444), contributed more to their QoL.

Conclusions: This study reported that both motor and non-motor symptoms contributed to QoL of PD patients. However, non-motor symptoms, especially mood and sleep dysfunction, affected the QoL more.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/quality-of-life-of-parkinsons-disease-patients-in-a-tertiary-hospital-in-hong-kong/