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Relationship between restless legs syndrome and various factors in pregnancy

L. čondić, S. Telarović (Zagreb, Croatia)

Meeting: 2019 International Congress

Abstract Number: 572

Keywords: Restless legs syndrome(RLS): Clinical features

Session Information

Date: Monday, September 23, 2019

Session Title: Restless Leg Syndrome, RBD and Other Sleep Disorders

Session Time: 1:45pm-3:15pm

Location: Les Muses Terrace, Level 3

Objective: The aim of this study was to examine the correlation between previous pregnancies and gestational age with the occurrence of RLS in pregnant women and the connection of RLS in the family with the onset of the disease in pregnant women and women who are not pregnant.

Background: RLS is a movement disorder characterized by unpleasant sensations in the legs described as a burning, tingling, etc. Symptoms become worse in the evening and are relieved by moving the limbs.

Method: The study was conducted on a sample of 231 pregnant women aged 18 to 50. The pregnant women were interviewed at the outpatient clinic of the Department of Gynaecology and Obstetrics. The study also included a control group of 231 age-compatible non-pregnant women. Women who met the international criteria for diagnosing the syndrome filled in a sociodemographic questionnaire.

Results: Statistically significant correlations between gestational ages greater than 16 weeks and RLS have been demonstrated, as well as the correlation of positive family history of this syndrome and its occurrence in the sample of pregnant women and non-pregnant women who were examined. A statistically significant link between the number of pregnancies and RLS in the sample of pregnant women tested has not been established.

Conclusion: RLS more often occurs after the 16th week of pregnancy and in pregnant women and non-pregnant women with cases of RLS in the family. In this study, no correlation has been proven between the number of previous pregnancies and RLS.

References: References 1. Ekbom K, Ulfberg J. Restless legs syndrome. Intern Med 2009;266(5):419-31. 2. Cotter PE, O’Keeffe ST. Restless leg syndrome: is it a real problem? Ther Clin Risk Manag 2006;2(4):465–475. 3. Srivanitchapoom P, Pandey S, Hallett M. Restless legs syndrome and pregnancy: A review. Parkinsonism Relat Disord 2014;20(7):716–722. 4. Patrick LR. Restless legs syndrome: pathophysiology and the role of iron and folate. Altern Med Rev 2007;12(2):101-12. 5. Gupta R, Dhyani M, Kendzerska T, Pandi-Perumal SR, BaHammam AS, Srivanitchapoom P, et al. Restless legs syndrome and pregnancy: prevalence, possible pathophysiological mechanisms and treatment. Acta Neurol Scand 2016;133(5):320–329. 6. Tan M, Bourjeily G. Shaking Up Perspectives of Restless Legs Syndrome in Pregnancy. J Clin Sleep Med 2017;13(7):857–858. 7. Facco FL, Kramer J, Ho KH, Zee PC, Grobman WA. Sleep disturbances in pregnancy. Obstet Gynecol 2010;115(1):77-83. 8. Chen PH, Liou KC, Chen CP, Cheng SJ. Risk factors and prevalence rate of restless legs syndrome among pregnant women in Taiwan. Sleep Med 2012;13(9):1153-7. 9. Suzuki K, Ohida T, Sone T, Takemura S, Yokoyama E, Miyake T. The prevalence of restless legs syndrome among pregnant women in Japan and the relationship between restless legs syndrome and sleep problems. Sleep 2003;26(6):673-7. 10. Lee KA, Zaffke ME, Baratte-Beebe K. Restless legs syndrome and sleep disturbance during pregnancy: the role of folate and iron. J Womens Health Gend Based Med 2001;10(4):335-41. 11. Neau JP, Marion P, Mathis S, Julian A, Godeneche G, Larrieu D, et al. Restless legs syndrome and pregnancy: follow-up of pregnant women before and after delivery. Eur Neurol 2010;64:361-6. 12. Didriksen M, Rigas AS, Allen RP, Burchell BJ, Di Angelantonio E, Nielsen MH, et al. Prevalence of restless legs syndrome and associated factors in an otherwise healthy population: results from the Danish Blood Donor Study. Sleep Med 2017;36:55-61. 13. Dhawan V, Ali M, Chaudhuri KR. Genetic aspects of restless legs syndrome. Postgrad Med J 2006;82(972):626–629. 14. Schormair B, Zhao C, Bell S, Tilch E, Salminen AV, Pütz B, et al. Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. Lancet Neurol 2017;16(11):898-907. 15. Bollu PC, Yelam A, Thakkar MM. Sleep Medicine: Restless Legs Syndrome. Mo Med 2018;115(4):380-387. 16. Dunietz GL, Lisabeth LD, Shedden K, Shamim-Uzzaman QA, Bullough AS, Chames MC, et al. Restless Legs Syndrome and Sleep-Wake Disturbances in Pregnancy. J Clin Sleep Med 2017;15;13(7):863-870. 17. Burman D. Sleep Disorders: Restless Legs Syndrome. FP Essent 2017;460:29-32.

To cite this abstract in AMA style:

L. čondić, S. Telarović. Relationship between restless legs syndrome and various factors in pregnancy [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/relationship-between-restless-legs-syndrome-and-various-factors-in-pregnancy/. Accessed June 15, 2025.
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