MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

MENU 
  • Home
  • Meetings Archive
    • 2024 International Congress
    • 2023 International Congress
    • 2022 International Congress
    • MDS Virtual Congress 2021
    • MDS Virtual Congress 2020
    • 2019 International Congress
    • 2018 International Congress
    • 2017 International Congress
    • 2016 International Congress
  • Keyword Index
  • Resources
  • Advanced Search

Retinal vascular change of Parkinson’s disease patients with orthostatic hypotension

JH. Ahn, D. Lee, JW. Cho, KA. Park, J. Youn (Seoul, Republic of Korea)

Meeting: 2022 International Congress

Abstract Number: 1428

Keywords: Parkinson’s

Category: Parkinson's Disease: Non-Motor Symptoms

Objective: In the present study, we investigated difference of microvasculature of Parkinson’s disease (PD) patients with orthostatic hypotension (OH) and without OH, using optical coherence tomography angiography (OCTA).

Background: OH is a common non-motor symptoms in PD, even in the early stage of disease. OH cause a recurrent hypoperfusion episodes and might damage on microvasculature. OCTA is non-invasive method and used for evaluating retinal microvasculature and it is a sensitive tool to detect microvascular change of the various disease including diabetes, systemic lupus erythematosus. Therefore, OCTA can help to detect microvascular damage in PD patients with OH.

Method: We recruited a total of 49 PD patients and performed OCTA and head-up tilt test (HUT). OH was defined as a fall of at least 20 mmHg in systolic blood pressure (SBP) and/or a 10 mmHg fall in diastolic blood pressure (DBP) within 3 minutes of HUT. Demographics, unified PD rating scale III (UPDRS III), Hoehn and Yahr stage (H&Y), levodopa equivalent daily dose (LEDD), Montreal Cognitive Assessment (MoCA) were investigated.

Results: There were no differences in age, sex, disease duration, UPDRS III, H&Y stage, LEDD and MoCA. Median of changes in SBP and DBP during the HUT were 28 and 11 in the OH group (OH+), and 10.0 and 3.0 in the without OH group (OH-), respectively. The OH+ had lower vascular density measured by OCTA in the superficial central (16.2%, p = 0.048), and deep central area(13.7%, p =0.010). However, there were no differences in the temporal, nasal, superior, and inferior area in both superficial and deep layers. The correlation analysis showed that the vascular density of deep central area was correlated with change of SBP (r = -0.330, p = 0.031) and, DBP (r = -0.382, p = 0.012).

Conclusion: The OH+ PD patients showed more microvasculature change measured by OCTA, than PD patients without OH. The larger decrease of blood pressure was associated with more microvasculature change. The results suggested that OCTA is a sensitive tool to detect microvascular damage induced by OH in PD.

OCTA table3

OCTA table2

OCTA table1

To cite this abstract in AMA style:

JH. Ahn, D. Lee, JW. Cho, KA. Park, J. Youn. Retinal vascular change of Parkinson’s disease patients with orthostatic hypotension [abstract]. Mov Disord. 2022; 37 (suppl 2). https://www.mdsabstracts.org/abstract/retinal-vascular-change-of-parkinsons-disease-patients-with-orthostatic-hypotension/. Accessed June 15, 2025.
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2022 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/retinal-vascular-change-of-parkinsons-disease-patients-with-orthostatic-hypotension/

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • Life expectancy with and without Parkinson’s disease in the general population
  • What is the appropriate sleep position for Parkinson's disease patients with orthostatic hypotension in the morning?
  • Patients with Essential Tremor Live Longer than their Relatives
  • Increased Risks of Botulinum Toxin Injection in Patients with Hypermobility Ehlers Danlos Syndrome: A Case Series
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • What is the appropriate sleep position for Parkinson's disease patients with orthostatic hypotension in the morning?
  • Life expectancy with and without Parkinson’s disease in the general population
  • The hardest symptoms that bother patients with Parkinson's disease
  • An Apparent Cluster of Parkinson's Disease (PD) in a Golf Community
  • Effect of marijuana on Essential Tremor: A case report
  • Increased Risks of Botulinum Toxin Injection in Patients with Hypermobility Ehlers Danlos Syndrome: A Case Series
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • Estimation of the 2020 Global Population of Parkinson’s Disease (PD)
  • Patients with Essential Tremor Live Longer than their Relatives
  • Help & Support
  • About Us
  • Cookies & Privacy
  • Wiley Job Network
  • Terms & Conditions
  • Advertisers & Agents
Copyright © 2025 International Parkinson and Movement Disorder Society. All Rights Reserved.
Wiley